PDB entry 1t5x

View 1t5x on RCSB PDB site
Description: HLA-DR1 in complex with a synthetic peptide (AAYSDQATPLLLSPR) and the superantigen SEC3-3B2
Class: immune system
Keywords: MHC class II; major histocompatibiloty complex protein; HLA-DR1; superantigen; antigen; peptide, IMMUNE SYSTEM
Deposited on 2004-05-05, released 2004-08-17
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-19.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.208
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA*0101
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1t5xa1, d1t5xa2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1*0101
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d1t5xb1, d1t5xb2
  • Chain 'C':
    Compound: 15-mer peptide fragment of Regulatory protein MIG1
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27705 (7-End)
      • insertion (0-6)
  • Chain 'D':
    Compound: Enterotoxin type C-3
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: SEC3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A0L5 (0-238)
      • engineered (42)
      • engineered (44-46)
    Domains in SCOPe 2.01: d1t5xd1, d1t5xd2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1t5xA (A:)
    keehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgala
    niavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtw
    lrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd
    a
    

    Sequence, based on observed residues (ATOM records): (download)
    >1t5xA (A:)
    ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
    avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
    ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefda
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1t5xB (B:)
    gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
    wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
    gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
    tspltvewra
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1t5xD (D:)
    esqpdpmpddlhksseftgtmgnmkylyddhyvsatkvksvdsffkwdliynisdkklkn
    ydkvktellnedlakkykdevvdvygsnyyvncyfsskdnvgkvtggktcmyggitkheg
    nhfdngnlqnvlvrvyenkrntisfevqtdkksvtaqeldikarnflinkknlyefnssp
    yetgyikfienngntfwydmmpapgdkfdqskylmmyndnktvdsksvkievhlttkng
    

    Sequence, based on observed residues (ATOM records): (download)
    >1t5xD (D:)
    esqpdpmpddlhksseftgtmgnmkylyddhyvsatkvksvdsffkwdliynisdkklkn
    ydkvktellnedlakkykdevvdvygsnyyvncyfsggktcmyggitkhegnhfdngnlq
    nvlvrvyenkrntisfevqtdkksvtaqeldikarnflinkknlyefnsspyetgyikfi
    enngntfwydmmpapgdkfdqskylmmyndnktvdsksvkievhlttkng