PDB entry 1t46
View 1t46 on RCSB PDB site
Description: structural basis for the autoinhibition and sti-571 inhibition of c-kit tyrosine kinase
Class: transferase activator
Keywords: KINASE, STRUCTURE, INHIBITOR, STI-571, Gleevec
Deposited on
2004-04-28, released
2004-06-15
The last revision prior to the SCOP 1.73 freeze date was dated
2004-08-03, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.19
AEROSPACI score: 0.57
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Species: HOMO SAPIENS
Gene: KIT
Database cross-references and differences (RAF-indexed):
- Uniprot P10721 (0-End)
- GB NP_000213
Domains in SCOP 1.73: d1t46a_ - Heterogens: PO4, STI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1t46A (A:)
gnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkm
lkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrr
krdsficsktspaimeddelaldledllsfsyqvakgmaflaskncihrdlaarnillth
gritkicdfglardikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwel
fslgsspypgmpvdskfykmikegfrmlspehapaemydimktcwdadplkrptfkqivq
liekqisestnhi
Sequence, based on observed residues (ATOM records): (download)
>1t46A (A:)
gnnyvyidptqlpydhkwefprnrlsfgktlgagafgkvveataygliksdaamtvavkm
lkpsahlterealmselkvlsylgnhmnivnllgactiggptlviteyccygdllnflrr
krdsflaldledllsfsyqvakgmaflaskncihrdlaarnillthgritkicdfglard
ikndsnyvvkgnarlpvkwmapesifncvytfesdvwsygiflwelfslgsspypgmpvd
skfykmikegfrmlspehapaemydimktcwdadplkrptfkqivqliekqisestn