PDB entry 1sk6

View 1sk6 on RCSB PDB site
Description: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
Class: Toxin, Lyase/Metal Binding Protein
Keywords: EF3 cAMP PPi CaM, Toxin, Lyase/Metal Binding Protein COMPLEX
Deposited on 2004-03-04, released 2004-06-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3.2 Å
R-factor: 0.25
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6a_
  • Chain 'B':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6b_
  • Chain 'C':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6c_
  • Chain 'D':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6d_
  • Chain 'E':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6e_
  • Chain 'F':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1sk6f_
  • Heterogens: CA, YB, CMP, POP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1sk6A (A:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6A (A:)
    ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
    gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
    elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
    rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
    llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
    eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
    akintiptsaefiknlssirrskkiagylsdyynsanhifsqekkrkisifrgiqaynei
    envlkskqiapeyknyfqylkeritnqvqlllthqfkllykqlnftenetdnfevfqkii
    d
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1sk6B (B:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6B (B:)
    dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
    ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
    kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
    ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnekqkgvtnllik
    ygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdneifi
    inpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkakin
    tipsdyynsanhifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritn
    qvqlllthqkllykqlnftenetdnfevfqkiid
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1sk6C (C:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6C (C:)
    ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
    gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
    elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
    rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
    llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
    eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
    akintiptsaefiknlssirrssvkkiagylsdyynsanhifsqekkrkisifrgiqayn
    eienvlkskqiapeyknyfqylkeritnqvqlllthqfkllykqlnftenetdnfevfqk
    iid
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1sk6D (D:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6D (D:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1sk6E (E:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6E (E:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1sk6F (F:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1sk6F (F:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta