PDB entry 1s26

View 1s26 on RCSB PDB site
Description: Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site
Class: toxin,lyase/metal binding protein
Keywords: ampcpp, edema factor, calmodulin, toxin,lyase/metal binding protein complex
Deposited on 2004-01-08, released 2004-04-13
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.264
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26a_
  • Chain 'B':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26b_
  • Chain 'C':
    Compound: calmodulin-sensitive adenylate cyclase
    Species: Bacillus anthracis [TaxId:1392]
    Gene: CYA, PXO1-122
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26c_
  • Chain 'D':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CAM1, CALM, CAM , CALM2, CAM2, CAMB , CALM3, CAM3, CAMC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26d_
  • Chain 'E':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CAM1, CALM, CAM , CALM2, CAM2, CAMB , CALM3, CAM3, CAMC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26e_
  • Chain 'F':
    Compound: calmodulin
    Species: Homo sapiens [TaxId:9606]
    Gene: CALM1, CAM1, CALM, CAM , CALM2, CAM2, CAMB , CALM3, CAM3, CAMC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1s26f_
  • Heterogens: CA, YB, APC

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1s26A (A:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26A (A:)
    ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
    gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
    elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
    rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
    llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
    eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
    akintiptsaefiknlssirrsssvkkiagylsdyynsanhifsqekkrkisifrgiqay
    neienvlkskqiapeyknyfqylkeritnqvqlllthqkfkllykqlnftenetdnfevf
    qkiid
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1s26B (B:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26B (B:)
    dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
    ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
    kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
    ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnekqkgvtnllik
    ygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdneifi
    inpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkakin
    tipsvkkiagylsdyynsanhifsqekkrkisifrgiqayneienvlkskqiapeyknyf
    qylkeritnqvqlllthqkfkllykqlnftenetdnfevfqkiid
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1s26C (C:)
    dridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnv
    hgkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlri
    eelkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfn
    wrnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvt
    nllikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekd
    neifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpit
    kakintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanh
    ifsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksn
    iefkllykqlnftenetdnfevfqkiidek
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26C (C:)
    ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
    gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
    elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
    rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
    llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
    eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
    akintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanhi
    fsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqkfkl
    lykqlnftenetdnfevfqkiid
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1s26D (D:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26D (D:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1s26E (E:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26E (E:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1s26F (F:)
    adqlteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgn
    gtidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdee
    vdemireadidgdgqvnyeefvqmmtak
    

    Sequence, based on observed residues (ATOM records): (download)
    >1s26F (F:)
    teeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgngtid
    fpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeevdem
    ireadidgdgqvnyeefvqmmta