PDB entry 1rej

View 1rej on RCSB PDB site
Description: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 1
Class: transferase
Keywords: protein kinase, natural product inhibitor, ligand binding, specificity determinants, conformational malleability
Deposited on 2003-11-06, released 2004-02-24
The last revision prior to the SCOP 1.73 freeze date was dated 2004-02-24, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.208
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: MUS MUSCULUS
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05132 (Start-349)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOP 1.73: d1reja_
  • Heterogens: B1L, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1rejA (A:)
gnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlv
khkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

    Sequence, based on observed residues (ATOM records): (download) 
    >1rejA (A:)
keflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamkild
kqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlrri
grfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkgrt
wtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgkv
rfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapfi
pkfkgpgdtsnfddyeeeeirvsinekcgkeftef