PDB entry 1re8

View 1re8 on RCSB PDB site
Description: Crystal structure of cAMP-dependent protein kinase complexed with balanol analog 2
Class: transferase
Keywords: protein kinase, natural product inhibitor, ligand binding, specificity determinants, conformational malleability
Deposited on 2003-11-06, released 2004-02-24
The last revision prior to the SCOP 1.73 freeze date was dated 2004-02-24, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.197
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: MUS MUSCULUS
    Gene: Prkaca, Pkaca
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05132 (Start-349)
      • modified residue (196)
      • modified residue (337)
    Domains in SCOP 1.73: d1re8a_
  • Heterogens: BD2, OCT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1re8A (A:)
    gnaaaakkgseqesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlv
    khkesgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
    eyvaggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
    qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
    dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
    dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef
    

    Sequence, based on observed residues (ATOM records): (download)
    >1re8A (A:)
    qesvkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyam
    kildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfsh
    lrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrv
    kgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekiv
    sgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkve
    apfipkfkgpgdtsnfddyeeeeirvsinekcgkeftef