PDB entry 1qcf

View 1qcf on RCSB PDB site
Description: crystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor
Class: tyrosine kinase
Keywords: tyrosine kinase-inhibitor complex, down-regulated kinase, ordered activation loop
Deposited on 1999-05-04, released 1999-06-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.215
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: haematopoetic cell kinase (hck)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08631 (Start-453)
      • (450-452)
    Domains in SCOPe 2.03: d1qcfa1, d1qcfa2, d1qcfa3
  • Heterogens: PP1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1qcfA (A:)
gamgsgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsny
varvdsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqg
dtvkhykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwek
daweipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktl
qhdklvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafi
eqrnyihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfg
sftiksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmr
cwknrpeerptfeyiqsvlddfytatesqyeeip

    Sequence, based on observed residues (ATOM records): (download) 
    >1qcfA (A:)
sgiriivvalydyeaihhedlsfqkgdqmvvleesgewwkarslatrkegyipsnyvarv
dsleteewffkgisrkdaerqllapgnmlgsfmirdsettkgsyslsvrdydprqgdtvk
hykirtldnggfyisprstfstlqelvdhykkgndglcqklsvpcmsskpqkpwekdawe
ipreslklekklgagqfgevwmatynkhtkvavktmkpgsmsveaflaeanvmktlqhdk
lvklhavvtkepiyiitefmakgslldflksdegskqplpklidfsaqiaegmafieqrn
yihrdlraanilvsaslvckiadfglarviedneytaregakfpikwtapeainfgsfti
ksdvwsfgillmeivtygripypgmsnpeviralergyrmprpencpeelynimmrcwkn
rpeerptfeyiqsvlddfytatesqyeeip