PDB entry 1q8w
View 1q8w on RCSB PDB site
Description: The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor Fasudil (HA-1077)
Class: Transferase/Transferase Inhibitor
Keywords: kinase-inhibitor-complex, phosphotransferase/inhibitor, camp, phosphorylation, serine/threonine-protein kinase, ATP-binding, pka, rho-kinase
Deposited on
2003-08-22, released
2003-12-16
The last revision prior to the SCOP 1.75 freeze date was dated
2003-12-16, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.22
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
Species: BOS TAURUS
Gene: PRKACA
Database cross-references and differences (RAF-indexed):
- Uniprot P00517 (Start-349)
- modified residue (138)
- modified residue (196)
- modified residue (337)
Domains in SCOP 1.75: d1q8wa_ - Chain 'B':
Compound: cAMP-dependent protein kinase inhibitor, alpha form
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: M77, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1q8wA (A:)
gnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlv
khmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvm
eyvpggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyi
qvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffa
dqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfatt
dwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
Sequence, based on observed residues (ATOM records): (download)
>1q8wA (A:)
svkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamki
ldkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvpggemfshlr
rigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkg
rtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsg
kvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveap
fipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
- Chain 'B':
No sequence available.