PDB entry 1q6s

View 1q6s on RCSB PDB site
Description: the structure of phosphotyrosine phosphatase 1b in complex with compound 9
Class: hydrolase
Keywords: phosphatase, secondary binding site, selectivity, hydrolase
Deposited on 2003-08-13, released 2003-09-30
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.196
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein-tyrosine phosphatase, non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1 OR PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031
      • cloning artifact (8-11)
    Domains in SCOPe 2.02: d1q6sa_
  • Chain 'B':
    Compound: protein-tyrosine phosphatase, non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1 OR PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (12-End)
      • cloning artifact (8-11)
    Domains in SCOPe 2.02: d1q6sb_
  • Heterogens: CL, MG, 214, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1q6sA (A:)
mdykddddklefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrd
vspfdhsriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvv
mlnrvmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqet
reilhfhyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcla
dtclllmdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvq
dqwkelshed

    Sequence, based on observed residues (ATOM records): (download) 
    >1q6sA (A:)
klefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsr
iklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmek
gslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhy
ttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmd
krkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgds

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1q6sB (B:)
mdykddddklefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrd
vspfdhsriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvv
mlnrvmekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqet
reilhfhyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcla
dtclllmdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvq
dqwkelshed

    Sequence, based on observed residues (ATOM records): (download) 
    >1q6sB (B:)
klefmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsr
iklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmek
gslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhy
ttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmd
krkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgds