PDB entry 1pyy

View 1pyy on RCSB PDB site
Description: Double mutant PBP2x T338A/M339F from Streptococcus pneumoniae strain R6 at 2.4 A resolution
Class: transpeptidase
Keywords: penicillin-binding protein, antibiotic resistance, peptidoglycan synthesis, cell wall, transmembrane, transpeptidase
Deposited on 2003-07-09, released 2003-09-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.218
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: penicillin-binding protein 2x
    Species: Streptococcus pneumoniae [TaxId:171101]
    Gene: PBPX
    Database cross-references and differences (RAF-indexed):
    • Uniprot P59676 (Start-701)
      • engineered (289-290)
    Domains in SCOPe 2.06: d1pyya1, d1pyya2, d1pyya3, d1pyya4
  • Heterogens: SO4, OSU, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pyyA (A:)
gtgtrfgtdlakeakkvhqttrtvpakrgtiydrngvpiaedatsynvyavidenyksat
gkilyvektqfnkvaevfhkyldmeesyvreqlsqpnlkqvsfgakgngityanmmsikk
eleaaevkgidfttspnrsypngqfassfiglaqlhenedgsksllgtsgmesslnsila
gtdgiityekdrlgnivpgteqvsqrtmdgkdvyttissplqsfmetqmdafqekvkgky
mtatlvsaktgeilattqrptfdadtkegitedfvwrdilyqsnyepgsafkvmmlaaai
dnntfpggevfnsselkiadatirdwdvnegltggrmmtfsqgfahssnvgmtlleqkmg
datwldylnrfkfgvptrfgltdeyagqlpadnivniaqssfgqgisvtqtqmiraftai
andgvmlepkfisaiydpndqtarksqkeivgnpvskdaasltrtnmvlvgtdpvygtmy
nhstgkptvtvpgqnvalksgtaqiadeknggylvgltdyifsavsmspaenpdfilyvt
vqqpehysgiqlgefanpilerasamkdslnlqttakaleqvsqqspypmpsvkdispgd
laeelrrnlvqpivvgtgtkiknssaeegknlapnqqvlilsdkaeevpdmygwtketae
tlakwlnielefqgsgstvqkqdvrantaikdikkitltlgd

    Sequence, based on observed residues (ATOM records): (download) 
    >1pyyA (A:)
pakrgtiydrngvpiaedatsynvyankvaevfhkyldmeesyvreqlvsfgakgngity
anmmspnrsypngqfassfiglaqlhenedgsksllgtsgmesslnsilagtddgkdvyt
tissplqsfmetqmdafqekvkgkymtatlvsaktgeilattqrptfdadtkegitedfv
wrdilyqsnyepgsafkvmmlaaaidnntfpggevfnsselkiadatirdwdvnegltgg
rmmtfsqgfahssnvgmtlleqkmgdatwldylnrfkfgvptrfgltdeyagqlpadniv
niaqssfgqgisvtqtqmiraftaiandgvmlepkfisaiydpndqtarksqkeivgnpv
skdaasltrtnmvlvgtdpvygtmynhstgkptvtvpgqnvalksgtaqiadeknggylv
gltdyifsavsmspaenpdfilyvtvqqpehysgiqlgefanpilerasamkdslnlqtt
akaleqvsqqspypmpsvkdispgdlaeelrrnlvqpivvgtgtkiknssaeegknlapn
qqvlilsdkaeevpdmygwtketaetlakwlnielefqgsgstvqkqdvrantaikdikk
itltlgd