PDB entry 1pyw

View 1pyw on RCSB PDB site
Description: Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
Class: immune system/protein binding/toxin
Keywords: MHC class II, Major histocompatibility protein complex, HLA-DR1, Influenza, Hemagglutinin, Superantigen, Antigen, IMMUNE SYSTEM-PROTEIN BINDING-TOXIN COMPLEX
Deposited on 2003-07-09, released 2003-12-09
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.209
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1pywa1, d1pywa2
  • Chain 'B':
    Compound: hla class II histocompatibility antigen, dr-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1pywb1, d1pywb2
  • Chain 'C':
    Compound: 9-residue influenza virus hemagglutinin related peptide FVKQNA(MAA)AL
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB 2VIU_A (0-8)
      • engineered (0)
      • engineered (5-7)
  • Chain 'D':
    Compound: Enterotoxin type C-3
    Species: Staphylococcus aureus [TaxId:158878]
    Gene: ENTC3 OR SAV2009 OR SA1817
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23313 (0-238)
      • engineered (42)
      • engineered (44-46)
    Domains in SCOPe 2.02: d1pywd1, d1pywd2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1pywA (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >1pywA (A:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwlr
ngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefda

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1pywB (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1pywD (D:)
esqpdpmpddlhksseftgtmgnmkylyddhyvsatkvksvdsffkwdliynisdkklkn
ydkvktellnedlakkykdevvdvygsnyyvncyfsskdnvgkvtggktcmyggitkheg
nhfdngnlqnvlvrvyenkrntisfevqtdkksvtaqeldikarnflinkknlyefnssp
yetgyikfienngntfwydmmpapgdkfdqskylmmyndnktvdsksvkievhlttkng

    Sequence, based on observed residues (ATOM records): (download) 
    >1pywD (D:)
esqpdpmpddlhksseftgtmgnmkylyddhyvsatkvksvdsffkwdliynisdkklkn
ydkvktellnedlakkykdevvdvygsnyyvncyfsggktcmyggitkhegnhfdngnlq
nvlvrvyenkrntisfevqtdkksvtaqeldikarnflinkknlyefnsspyetgyikfi
enngntfwydmmpapgdkfdqskylmmyndnktvdsksvkievhlttkng