PDB entry 1p8d

View 1p8d on RCSB PDB site
Description: X-Ray Crystal Structure of LXR Ligand Binding Domain with 24(S),25-epoxycholesterol
Class: membrane protein/protein binding
Keywords: LXR, epoxycholesterol, nuclear receptor, steroid receptor, liver X receptor, transcription
Deposited on 2003-05-06, released 2003-07-08
The last revision prior to the SCOP 1.73 freeze date was dated 2003-07-22, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.214
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: oxysterols receptor lxr-beta
    Species: HOMO SAPIENS
    Gene: NR1H2 OR LXRB OR UNR OR NER
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1p8da_
  • Chain 'B':
    Compound: oxysterols receptor lxr-beta
    Species: HOMO SAPIENS
    Gene: NR1H2 OR LXRB OR UNR OR NER
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1p8db_
  • Chain 'C':
    Compound: Nuclear Receptor Coactivator 1 isoform 3
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB NP_671766
  • Chain 'D':
    Compound: Nuclear Receptor Coactivator 1 isoform 3
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB NP_671766
  • Heterogens: CO1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1p8dA (A:)
gsegegvqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplgadpqsrdarqqrfahf
telaiisvqeivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflk
dftyskddfhraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgr
vealqqpyveallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklpp
llseiwdvhe

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8dA (A:)
vqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplqsrdarqqrfahftelaiisvqe
ivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflkdftyskddfh
raglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealqqpyve
allsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllseiwdvhe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1p8dB (B:)
gsegegvqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplgadpqsrdarqqrfahf
telaiisvqeivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflk
dftyskddfhraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgr
vealqqpyveallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklpp
llseiwdvhe

    Sequence, based on observed residues (ATOM records): (download) 
    >1p8dB (B:)
vqltaaqelmiqqlvaaqlqcnkrsfsdqpkvtpwplgasrdarqqrfahftelaiisvq
eivdfakqvpgflqlgredqiallkastieimlletarrynhetecitflkdftyskddf
hraglqvefinpifefsramrrlglddaeyalliainifsadrpnvqepgrvealqqpyv
eallsytrikrpqdqlrfprmlmklvslrtlssvhseqvfalrlqdkklppllseiwdv

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.