PDB entry 1p2n

View 1p2n on RCSB PDB site
Description: Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin
Class: hydrolase/hydrolase inhibitor
Keywords: trypsin; chymotrypsin; serine proteinase; bovine pancreatic trypsin inhibitor; protein-protein interaction; non-cognate binding; S1 pocket; primary specificity; crystal structure
Deposited on 2003-04-15, released 2004-04-20
The last revision prior to the SCOP 1.73 freeze date was dated 2004-04-20, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.199
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: chymotrypsinogen a
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1p2na_
  • Chain 'B':
    Compound: pancreatic trypsin inhibitor
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00974 (0-57)
      • engineered (14)
      • engineered (51)
    Domains in SCOP 1.73: d1p2nb_
  • Chain 'C':
    Compound: chymotrypsinogen a
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1p2nc_
  • Chain 'D':
    Compound: pancreatic trypsin inhibitor
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00974 (0-57)
      • engineered (14)
      • engineered (51)
    Domains in SCOP 1.73: d1p2nd_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1p2nA (A:)
cgvpaiqpvlsglsrivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgv
ttsdvvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsa
vclpsasddfaagttcvttgwgltrytnantpdrlqqaslpllsntnckkywgtkikdam
icagasgvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqq
tlaan

    Sequence, based on observed residues (ATOM records): (download) 
    >1p2nA (A:)
cgvpaiqpvlsivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgvttsd
vvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsavclp
sasddfaagttcvttgwgltryantpdrlqqaslpllsntnckkywgtkikdamicagas
gvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqqtlaan

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1p2nB (B:)
rpdfcleppytgpclariiryfynakaglcqtfvyggcrakrnnfksaedclrtcgga

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1p2nC (C:)
cgvpaiqpvlsglsrivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgv
ttsdvvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsa
vclpsasddfaagttcvttgwgltrytnantpdrlqqaslpllsntnckkywgtkikdam
icagasgvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqq
tlaan

    Sequence, based on observed residues (ATOM records): (download) 
    >1p2nC (C:)
cgvpaiqpvlsivngeeavpgswpwqvslqdktgfhfcggslinenwvvtaahcgvttsd
vvvagefdqgsssekiqklkiakvfknskynsltinnditllklstaasfsqtvsavclp
sasddfaagttcvttgwgltryantpdrlqqaslpllsntnckkywgtkikdamicagas
gvsscmgdsggplvckkngawtlvgivswgsstcststpgvyarvtalvnwvqqtlaan

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1p2nD (D:)
rpdfcleppytgpclariiryfynakaglcqtfvyggcrakrnnfksaedclrtcgga