PDB entry 1p22
View 1p22 on RCSB PDB site
Description: Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity on the SCFbeta-TrCP1 ubiquitin ligase
Class: signaling protein
Keywords: Ubiquitination, degradation, SIGNALING PROTEIN
Deposited on
2003-04-14, released
2003-07-08
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.233
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: F-box/WD-repeat protein 1A
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d1p22a1, d1p22a2 - Chain 'B':
Compound: skp1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d1p22b1, d1p22b2 - Chain 'C':
Compound: beta-catenin
Species: Homo sapiens [TaxId:9606]
Gene: CTNNB1 OR CTNNB
Database cross-references and differences (RAF-indexed):
- Uniprot P35222
- modified residue (14)
- modified residue (18)
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1p22A (A:)
spaimlqrdfitalpargldhiaenilsyldakslcaaelvckewyrvtsdgmlwkklie
rmvrtdslwrglaerrgwgqylfknkppdgnappnsfyralypkiiqdietiesnwrcgr
hslqrihcrsetskgvyclqyddqkivsglrdntikiwdkntleckriltghtgsvlclq
yderviitgssdstvrvwdvntgemlntlihhceavlhlrfnngmmvtcskdrsiavwdm
asptditlrrvlvghraavnvvdfddkyivsasgdrtikvwntstcefvrtlnghkrgia
clqyrdrlvvsgssdntirlwdiecgaclrvlegheelvrcirfdnkrivsgaydgkikv
wdlvaaldprapagtlclrtlvehsgrvfrlqfdefqivssshddtiliwdflndpaaqa
epprspsrtytyisr
Sequence, based on observed residues (ATOM records): (download)
>1p22A (A:)
spaimlqrdfitalpargldhiaenilsyldakslcaaelvckewyrvtsdgmlwkklie
rmvrtdslwrglaerrgwgqylfppnsfyralypkiiqdietiesnwrcgrhslqrihcr
setskgvyclqyddqkivsglrdntikiwdkntleckriltghtgsvlclqyderviitg
ssdstvrvwdvntgemlntlihhceavlhlrfnngmmvtcskdrsiavwdmasptditlr
rvlvghraavnvvdfddkyivsasgdrtikvwntstcefvrtlnghkrgiaclqyrdrlv
vsgssdntirlwdiecgaclrvlegheelvrcirfdnkrivsgaydgkikvwdlvaaldp
rapagtlclrtlvehsgrvfrlqfdefqivssshddtiliwd
- Chain 'B':
Sequence, based on SEQRES records: (download)
>1p22B (B:)
mpsiklqssdgeifevdveiakqsvtiktmledlgmdpvplpnvnaailkkviqwcthhk
ddppddipvwdqeflkvdqgtlfelilaanyldikglldvtcktvanmikgktpeeirkt
fnikndfteeeeaqvrkenqwceek
Sequence, based on observed residues (ATOM records): (download)
>1p22B (B:)
psiklqssdgeifevdveiakqsvtiktmledlgmdpvplpnvnaailkkviqwcthhip
vwdqeflkvdqgtlfelilaanyldikglldvtcktvanmikgktpeeirktfnikndft
eeeeaqvrken
- Chain 'C':
No sequence available.