PDB entry 1oph

View 1oph on RCSB PDB site
Description: non-covalent complex between alpha-1-pi-pittsburgh and s195a trypsin
Class: hydrolase/hydrolase inhibitor
Keywords: serine proteinase inhibitor, michaelis-like complex, serpin, alpha-1 antitrypsin, trypsin
Deposited on 2003-03-05, released 2003-08-05
The last revision prior to the SCOP 1.75 freeze date was dated 2004-01-13, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.19
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-1-antitrypsin precursor
    Species: HOMO SAPIENS
    Gene: SERPINA1 OR PI OR AAT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01009 (Start-393)
      • engineered (50)
      • engineered (58)
      • engineered (67)
      • engineered (69)
      • engineered (231)
      • engineered (357)
      • engineered (373)
      • engineered (380)
      • engineered (386)
    Domains in SCOP 1.75: d1opha_
  • Chain 'B':
    Compound: Trypsinogen, cationic precursor
    Species: BOS TAURUS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00760 (Start-242)
      • engineered (196)
    Domains in SCOP 1.75: d1ophb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ophA (A:)
mdpqgdaaqktdtshhdqdhptfnkitpnlaefafslyrqlahqsnstnilfspvsiaaa
famlslgakgdthdeileglnfnlteipeaqihegfqellrtlnqpdsqlqlttgnglfl
seglklvdkfledvkklyhseaftvnfgdteeakkqindyvekgtqgkivdlvkeldrdt
vfalvnyiffkgkwerpfevkdteeedfhvdqvttvkvpmmkrlgmfniqhskklsswvl
lmkylgnataifflpdegklqhlenelthdiitkflenedrrsaslhlpklsitgtydlk
svlgqlgitkvfsngadlsgvteeaplklskavhkavltidekgteaagamfleaiprsi
ppevkfnkpfvfliieqntkaplfmgrvvnptqk

    Sequence, based on observed residues (ATOM records): (download) 
    >1ophA (A:)
hptfnkitpnlaefafslyrqlahqsnstnilfspvsiaaafamlslgakgdthdeileg
lnfnlteipeaqihegfqellrtlnqpdsqlqlttgnglflseglklvdkfledvkklyh
seaftvnfgdteeakkqindyvekgtqgkivdlvkeldrdtvfalvnyiffkgkwerpfe
vkdteeedfhvdqvttvkvpmmkrlgmfniqhskklsswvllmkylgnataifflpdegk
lqhlenelthdiitkflenedrrsaslhlpklsitgtydlksvlgqlgitkvfsngadls
gvteeaplklskavhkavltidekgteaagamfleaiprsippevkfnkpfvfliieqnt
kaplfmgrvvnptqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ophB (B:)
fiflallgaavafpvddddkivggytcgantvpyqvslnsgyhfcggslinsqwvvsaah
cyksgiqvrlgedninvvegneqfisasksivhpsynsntlnndimliklksaaslnsrv
asislptscasagtqclisgwgntkssgtsypdvlkclkapilsdsscksaypgqitsnm
fcagyleggkdscqgdaggpvvcsgklqgivswgsgcaqknkpgvytkvcnyvswikqti
asn

    Sequence, based on observed residues (ATOM records): (download) 
    >1ophB (B:)
ivggytcgantvpyqvslnsgyhfcggslinsqwvvsaahcyksgiqvrlgedninvveg
neqfisasksivhpsynsntlnndimliklksaaslnsrvasislptscasagtqclisg
wgntkssgtsypdvlkclkapilsdsscksaypgqitsnmfcagyleggkdscqgdaggp
vvcsgklqgivswgsgcaqknkpgvytkvcnyvswikqtiasn