PDB entry 1og0

View 1og0 on RCSB PDB site
Description: crystal structure of the mutant g226s of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with phenylalanine and manganese
Class: lyase
Keywords: beta-alpha-barrel, lyase
Deposited on 2003-04-22, released 2004-04-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-06-16, with a file datestamp of 2009-06-12.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.213
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0a_
  • Chain 'B':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0b_
  • Chain 'C':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0c_
  • Chain 'D':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0d_
  • Chain 'E':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0e_
  • Chain 'F':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449 (Start-369)
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0f_
  • Chain 'G':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0g_
  • Chain 'H':
    Compound: phospho-2-dehydro-3-deoxyheptonate aldolase
    Species: SACCHAROMYCES CEREVISIAE [TaxId:4932]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32449
      • engineered mutation (225)
    Domains in SCOPe 2.06: d1og0h_
  • Heterogens: PHE, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1og0A (A:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0A (A:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylwkglindpdvnntfninkglqsarqlf
vnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkngtd
gtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksvaea
kaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesninegnqg
ipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1og0B (B:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0B (B:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekpvgwkglindpdvnntfninkglqsa
rqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfk
ngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqgipaegkalkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1og0C (C:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0C (C:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekwkglindpdvnntfninkglqsarq
lfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkng
tdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksva
eakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesninegn
qgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1og0D (D:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0D (D:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekprgwkglindpdvnntfninkglqs
arqlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgf
kngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydak
svaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnin
egnqgipaegkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1og0E (E:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0E (E:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylglindpdvnntfninkglqsarqlfvn
ltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkngtdgt
lnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksvaeaka
qlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesninegnqgip
kygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1og0F (F:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0F (F:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekgwkglindpdvnntfninkglqsar
qlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkn
gtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqgipgkaglkygvsitdacigwettedvlrklaaavrqrrevnkk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1og0G (G:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0G (G:)
aeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcsi
hdleaaqeyalrlkklsdelkgdlsiimraylekpwkglindpdvnntfninkglqsarq
lfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkng
tdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksva
eakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesninegn
qipaeaglkygvsitdacigwettedvlrklaaavrqrrevnk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1og0H (H:)
msespmfaangmpkvnqgaeedvrilgydplaspallqvqipatptsletakrgrreaid
iitgkddrvlvivgpcsihdleaaqeyalrlkklsdelkgdlsiimraylekprttvgwk
glindpdvnntfninkglqsarqlfvnltniglpigsemldtispqyladlvsfgaigar
ttesqlhrelasglsfpvgfkngtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkg
nehcfvilrggkkgtnydaksvaeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvc
eqiangenaitgvmiesninegnqgipaegkaglkygvsitdacigwettedvlrklaaa
vrqrrevnkk

    Sequence, based on observed residues (ATOM records): (download) 
    >1og0H (H:)
gaeedvrilgydplaspallqvqipatptsletakrgrreaidiitgkddrvlvivgpcs
ihdleaaqeyalrlkklsdelkgdlsiimraylekpwkglindpdvnntfninkglqsar
qlfvnltniglpigsemldtispqyladlvsfgaigarttesqlhrelasglsfpvgfkn
gtdgtlnvavdacqaaahshhfmsvtkhgvaaitttkgnehcfvilrggkkgtnydaksv
aeakaqlpagsnglmidyshgnsnkdfrnqpkvndvvceqiangenaitgvmiesnineg
nqgipaaglkygvsitdacigwettedvlrklaaavrqrrevnk