PDB entry 1nwl

View 1nwl on RCSB PDB site
Description: Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic
Class: hydrolase
Keywords: protein-small molecule inhibitor complex, HYDROLASE
Deposited on 2003-02-06, released 2003-04-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.21
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein-tyrosine phosphatase, non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (0-End)
      • engineered (31)
      • engineered (46)
      • engineered (91)
    Domains in SCOPe 2.04: d1nwla_
  • Heterogens: MG, 964, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1nwlA (A:)
    memekefeqidksgswaaiyqdirheasdfpsrvaklpknknrnrycdvspfdhsriklh
    qedndyinaslikmeeaqrsyiltqgplpntvghfwemvweqksrgvvmlnrvmekgslk
    caqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwp
    dfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkd
    pssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkelshed
    

    Sequence, based on observed residues (ATOM records): (download)
    >1nwlA (A:)
    memekefeqidksgswaaiyqdirheasdfpsrvaklpknknrnrycdvspfdhsriklh
    qedndyinaslikmeeaqrsyiltqgplpntvghfwemvweqksrgvvmlnrvmekgslk
    caqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwp
    dfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkd
    pssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimg