PDB entry 1nql

View 1nql on RCSB PDB site
Description: Structure of the extracellular domain of human epidermal growth factor (EGF) receptor in an inactive (low pH) complex with EGF.
Class: hormone/growth factor receptor
Keywords: cell surface receptor, tyrosine kinase, glycoprotein, endosomal, growth factor, auto-inhibition, HORMONE-GROWTH FACTOR RECEPTOR COMPLEX
Deposited on 2003-01-21, released 2003-03-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.247
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • GB NP_005219
    Domains in SCOPe 2.07: d1nqla1, d1nqla2, d1nqla3, d1nqla4, d1nqla5
  • Chain 'B':
    Compound: epidermal growth factor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1nqlb_
  • Heterogens: NAG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1nqlA (A:)
    leekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqe
    vagyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeil
    hgavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgage
    encqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtc
    pplmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvr
    kckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsftht
    ppldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvsln
    itslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgq
    vchalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclp
    qamnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnc
    tygctgpglegcptngpkhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >1nqlA (A:)
    ekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqeva
    gyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeilhg
    avrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgageen
    cqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtcpp
    lmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvrkc
    kkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtpp
    ldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslnit
    slglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgensckatgqvc
    halcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclpqa
    mnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpncty
    gctgpglegcpt
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1nqlB (B:)
    nsdsecplshdgyclhdgvcmyiealdkyacncvvgyigercqyrdlkwwelr
    

    Sequence, based on observed residues (ATOM records): (download)
    >1nqlB (B:)
    dsecplshdgyclhdgvcmyiealdkyacncvvgyigercqyrdlkww