PDB entry 1nq0

View 1nq0 on RCSB PDB site
Description: TR Receptor Mutations Conferring Hormone Resistance and Reduced Corepressor Release Exhibit Decreased Stability in the Nterminal LBD
Class: hormone/growth factor receptor
Keywords: thyroid hormone receptor
Deposited on 2003-01-20, released 2003-04-15
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-15, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.218
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thyroid hormone receptor Beta-1
    Species: HOMO SAPIENS
    Gene: THRB OR NR1A2 OR ERBA2 OR THR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10828 (Start-64)
      • cloning artifact (0-2)
      • engineered (35)
    Domains in SCOP 1.73: d1nq0a_
  • Heterogens: 4HY, ARS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1nq0A (A:)
aameelqksighkpeptdeeweliktvteahvatntqgshwkqkrkflpedigqapivna
peggkvdleafshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraa
vrydpesetltlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavll
mssdrpglacveriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasr
flhmkvecptelfpplflevfed

    Sequence, based on observed residues (ATOM records): (download) 
    >1nq0A (A:)
aameelqksighkpeptdeeweliktvteahvatntqgshwkqkrkflpedigqkvdlea
fshftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetl
tlngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglac
veriekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecpt
elfpplflevfed