PDB entry 1ms4

View 1ms4 on RCSB PDB site
Description: Triclinic form of Trypanosoma cruzi trans-sialidase
Class: hydrolase
Keywords: sialidase, trans-glycosylation, beta-propeller, protein-carbohydrate interaction
Deposited on 2002-09-19, released 2003-03-25
The last revision prior to the SCOP 1.73 freeze date was dated 2003-03-25, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: 0.218
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Trans-sialidase
    Species: Trypanosoma cruzi
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q26964 (14-End)
      • engineered (71)
      • see remark 999 (275)
      • see remark 999 (489)
      • see remark 999 (497)
      • engineered (508-509)
      • engineered (533)
      • see remark 999 (571)
      • engineered (606)
      • engineered (610)
      • engineered (612)
    Domains in SCOP 1.73: d1ms4a1, d1ms4a2
  • Chain 'B':
    Compound: Trans-sialidase
    Species: Trypanosoma cruzi
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q26964 (14-End)
      • engineered (71)
      • see remark 999 (275)
      • see remark 999 (489)
      • see remark 999 (497)
      • engineered (508-509)
      • engineered (533)
      • see remark 999 (571)
      • engineered (606)
      • engineered (610)
      • engineered (612)
    Domains in SCOP 1.73: d1ms4b1, d1ms4b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ms4A (A:)
mggshhhhhhgmaslapgssrvelfkrqsskvpfekdgkvtervvhsfrlpalvnvdgvm
vaiadaryetsfdnslidtvakysvddgetwetqiaiknsrassvsrvvdptvivkgnkl
yvlvgsynssrsywtshgdardwdillavgevtkstaggkitasikwgspvslkeffpae
megmhtnqflggagvaivasngnlvypvqvtnkkkqvfskifysedegktwkfgkgrsaf
gcsepvalewegkliintrvdyrrrlvyessdmgntwleavgtlsrvwgpspksnqpgsq
ssftavtiegmrvmlfthplnfkgrwlrdrlnlwltdnqriynvgqvsigdensayssvl
ykddklyclheinsnevyslvfarlvgelriiksvlqswknwdshlssictpadpaasss
ergcgpavttvglvgflshsatktewedayrcvnastanaervpnglkfagvgggalwpv
sqqgqnqryhfanhaftlvasvtihevpkgaspllgasldssggkkllglsydkrhqwqp
iygstpvtptgswemgkryhvvltmankigsvyidgeplegsgqtvvpdertpdishfyv
ggykrsgmptdsrvtvnnvllynrqlnaeeirtlflsqdligteahmd

    Sequence, based on observed residues (ATOM records): (download) 
    >1ms4A (A:)
lapgssrvelfkrqsskvpfekdgkvtervvhsfrlpalvnvdgvmvaiadaryetsfdn
slidtvakysvddgetwetqiaiknsrassvsrvvdptvivkgnklyvlvgsynssrsyw
tshgdardwdillavgevtkstaggkitasikwgspvslkeffpaemegmhtnqflggag
vaivasngnlvypvqvtnkkkqvfskifysedegktwkfgkgrsafgcsepvalewegkl
iintrvdyrrrlvyessdmgntwleavgtlsrvwgpspksnqpgsqssftavtiegmrvm
lfthplnfkgrwlrdrlnlwltdnqriynvgqvsigdensayssvlykddklyclheins
nevyslvfarlvgelriiksvlqswknwdshlssictpagcgpavttvglvgflshsatk
tewedayrcvnastanaervpnglkfagvgggalwpvsqqgqnqryhfanhaftlvasvt
ihevpkgaspllgasldssggkkllglsydkrhqwqpiygstpvtptgswemgkryhvvl
tmankigsvyidgeplegsgqtvvpdertpdishfyvggykrsgmptdsrvtvnnvllyn
rqlnaeeirtlflsqdligteah

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ms4B (B:)
mggshhhhhhgmaslapgssrvelfkrqsskvpfekdgkvtervvhsfrlpalvnvdgvm
vaiadaryetsfdnslidtvakysvddgetwetqiaiknsrassvsrvvdptvivkgnkl
yvlvgsynssrsywtshgdardwdillavgevtkstaggkitasikwgspvslkeffpae
megmhtnqflggagvaivasngnlvypvqvtnkkkqvfskifysedegktwkfgkgrsaf
gcsepvalewegkliintrvdyrrrlvyessdmgntwleavgtlsrvwgpspksnqpgsq
ssftavtiegmrvmlfthplnfkgrwlrdrlnlwltdnqriynvgqvsigdensayssvl
ykddklyclheinsnevyslvfarlvgelriiksvlqswknwdshlssictpadpaasss
ergcgpavttvglvgflshsatktewedayrcvnastanaervpnglkfagvgggalwpv
sqqgqnqryhfanhaftlvasvtihevpkgaspllgasldssggkkllglsydkrhqwqp
iygstpvtptgswemgkryhvvltmankigsvyidgeplegsgqtvvpdertpdishfyv
ggykrsgmptdsrvtvnnvllynrqlnaeeirtlflsqdligteahmd

    Sequence, based on observed residues (ATOM records): (download) 
    >1ms4B (B:)
lapgssrvelfkrqsskvpfekdgkvtervvhsfrlpalvnvdgvmvaiadaryetsfdn
slidtvakysvddgetwetqiaiknsrassvsrvvdptvivkgnklyvlvgsynssrsyw
tshgdardwdillavgevtkstaggkitasikwgspvslkeffpaemegmhtnqflggag
vaivasngnlvypvqvtnkkkqvfskifysedegktwkfgkgrsafgcsepvalewegkl
iintrvdyrrrlvyessdmgntwleavgtlsrvwgpspksnqpgsqssftavtiegmrvm
lfthplnfkgrwlrdrlnlwltdnqriynvgqvsigdensayssvlykddklyclheins
nevyslvfarlvgelriiksvlqswknwdshlssictpagcgpavttvglvgflshsatk
tewedayrcvnastanaervpnglkfagvgggalwpvsqqgqnqryhfanhaftlvasvt
ihevpkgaspllgasldssggkkllglsydkrhqwqpiygstpvtptgswemgkryhvvl
tmankigsvyidgeplegsgqtvvpdertpdishfyvggykrsgmptdsrvtvnnvllyn
rqlnaeeirtlflsqdligteah