PDB entry 1mf8

View 1mf8 on RCSB PDB site
Description: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Class: hydrolase/isomerase/immunosuppressant
Keywords: hydrolase-isomerase-immunosuppressant complex, calcineurin-cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, hydrolase, isomerase
Deposited on 2002-08-09, released 2002-10-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.25
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: calmodulin-dependent calcineurin a subunit, alpha isoform
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1mf8a_
  • Chain 'B':
    Compound: calcineurin b subunit isoform 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1mf8b_
  • Chain 'C':
    Compound: Peptidyl-prolyl cis-trans isomerase A
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1mf8c_
  • Chain 'D':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Heterogens: CA, PO4

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1mf8A (A:)
    avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
    didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
    ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
    gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
    ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
    avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlnicsddelgs
    eedgfdgataaar
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mf8A (A:)
    avpfppshrltakevfdndgkprvdilkahlmkegrleesvalriitegasilrqeknll
    didapvtvcgdihgqffdlmklfevggspantrylflgdyvdrgyfsiecvlylwalkil
    ypktlfllrgnhecrhlteyftfkqeckikyservydacmdafdclplaalmnqqflcvh
    gglspeintlddirkldrfkeppaygpmcdilwsdpledfgnektqehfthntvrgcsyf
    ysypavceflqhnnllsilraheaqdagyrmyrksqttgfpslitifsapnyldvynnka
    avlkyennvmnirqfncsphpywlpnfmdvftwslpfvgekvtemlvnvlni
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1mf8B (B:)
    mgneasyplemcshfdadeikrlgkrfkkldldnsgslsveefmslpelqqnplvqrvid
    ifdtdgngevdfkefiegvsqfsvkgdkeqklrfafriydmdkdgyisngelfqvlkmmv
    gnnlkdtqlqqivdktiinadkdgdgrisfeefcavvggldihkkmvvdv
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mf8B (B:)
    syplemcshfdadeikrlgkrfkkldldnsgslsveefmslpelqqnplvqrvidifdtd
    gngevdfkefiegvsqfsvkgdkeqklrfafriydmdkdgyisngelfqvlkmmvgnnlk
    dtqlqqivdktiinadkdgdgrisfeefcavvggldihkkmvvd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1mf8C (C:)
    mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
    mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
    wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgqle
    

    Sequence, based on observed residues (ATOM records): (download)
    >1mf8C (C:)
    mvnptvffdiavdgeplgrvsfelfadkvpktaenfralstgekgfgykgscfhriipgf
    mcqggdftrhngtggksiygekfedenfilkhtgpgilsmanagpntngsqffictakte
    wldgkhvvfgkvkegmniveamerfgsrngktskkitiadcgql
    

  • Chain 'D':
    No sequence available.