PDB entry 1m75

View 1m75 on RCSB PDB site
Description: Crystal Structure of the N208S Mutant of L-3-Hydroxyacyl-COA Dehydrogenase in Complex with NAD and Acetoacetyl-COA
Class: oxidoreductase
Keywords: rossmann fold, dehydrogenase
Deposited on 2002-07-18, released 2004-02-03
The last revision prior to the SCOP 1.73 freeze date was dated 2005-07-19, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.228
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (207)
    Domains in SCOP 1.73: d1m75a1, d1m75a2
  • Chain 'B':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (207)
    Domains in SCOP 1.73: d1m75b1, d1m75b2
  • Heterogens: CAA, NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1m75A (A:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfk
rldkfaaehtifasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivsrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1m75A (A:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfkrldkfaaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivsrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1m75B (B:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfk
rldkfaaehtifasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivsrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1m75B (B:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfkrldkfaaehti
fasntsslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivsrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk