PDB entry 1lwe

View 1lwe on RCSB PDB site
Description: crystal structure of m41l/t215y mutant hiv-1 reverse transcriptase (rtmn) in complex with nevirapine
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, azt, 3tc, nrti, nevirapine, drug resistance mutations, transferase
Deposited on 2002-05-31, released 2002-10-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.81 Å
R-factor: 0.213
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hiv-1 reverse transcriptase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 POL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-End)
      • engineered (40)
      • engineered (214)
      • modified residue (279)
    Domains in SCOPe 2.06: d1lwea1, d1lwea2
  • Chain 'B':
    Compound: hiv-1 reverse transcriptase
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: HIV-1 POL
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (40)
      • engineered (214)
    Domains in SCOPe 2.06: d1lweb_
  • Heterogens: PO4, NVP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lweA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1lweA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkstkklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwtvqpivlpekds
wtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilk
epvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqltea
vqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlek
epivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelqaiylalqdsgl
evnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqvdkl
vsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1lweB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglytpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1lweB (B:)
etvpvklkpgmdgpkvkqwplteekikalveictelekegkiskigpenpyntpvfaikk
kdstkwrklvdfrelnkrtqdfiphpaglkkkksvtvldvgdayfsvpldedfrkytaft
ipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgs
dleigqhrtkieelrqhllrwglyyelhpdkwtvqpivlpekdswtvndiqklvgklnwa
sqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdlia
eiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktp
kfklpiqketwetwwteywqatwipewefvntpplvklwyq