PDB entry 1lso

View 1lso on RCSB PDB site
Description: Crystal Structure of the S137A mutant of L-3-Hydroxyacyl-CoA Dehydrogenase in Complex with NAD
Class: oxidoreductase
Keywords: Rossmann fold
Deposited on 2002-05-17, released 2004-02-03
The last revision prior to the SCOP 1.73 freeze date was dated 2004-02-03, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.22
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (136)
    Domains in SCOP 1.73: d1lsoa1, d1lsoa2
  • Chain 'B':
    Compound: 3-hydroxyacyl-CoA dehydrogenase
    Species: HOMO SAPIENS
    Gene: HCDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16836 (Start-301)
      • engineered (136)
    Domains in SCOP 1.73: d1lsob1, d1lsob2
  • Heterogens: NAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1lsoA (A:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfk
rldkfaaehtifasntaslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1lsoA (A:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfkrldkfaaehti
fasntaslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1lsoB (B:)
sssstasasakkiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgiee
slrkvakkkfaenpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfk
rldkfaaehtifasntaslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqk
tfeslvdfskalgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklga
gypmgpfelldyvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfyk
yk

    Sequence, based on observed residues (ATOM records): (download) 
    >1lsoB (B:)
kiivkhvtviggglmgagiaqvaaatghtvvlvdqtedilakskkgieeslrkvakkkfa
enpkagdefvektlstiatstdaasvvhstdlvveaivenlkvknelfkrldkfaaehti
fasntaslqitsianattrqdrfaglhffnpvpvmklveviktpmtsqktfeslvdfska
lgkhpvsckdtpgfivnrllvpylmeairlyergdaskedidtamklgagypmgpfelld
yvgldttkfivdgwhemdaenplhqpspslnklvaenkfgkktgegfykyk