PDB entry 1kkq
View 1kkq on RCSB PDB site
Description: Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Class: transcription
Keywords: nuclear corepressor nuclear hormone receptors antagonist, TRANSCRIPTION
Deposited on
2001-12-10, released
2002-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-11, with a file datestamp of
2017-10-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: peroxisome proliferator activated receptor
Species: Homo sapiens [TaxId:9606]
Gene: Human
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1kkqa_ - Chain 'B':
Compound: peroxisome proliferator activated receptor
Species: Homo sapiens [TaxId:9606]
Gene: Human
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1kkqb_ - Chain 'C':
Compound: peroxisome proliferator activated receptor
Species: Homo sapiens [TaxId:9606]
Gene: Human
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1kkqc_ - Chain 'D':
Compound: peroxisome proliferator activated receptor
Species: Homo sapiens [TaxId:9606]
Gene: Human
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1kkqd_ - Chain 'E':
Compound: nuclear receptor co-repressor 2
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: nuclear receptor co-repressor 2
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'G':
Compound: nuclear receptor co-repressor 2
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: nuclear receptor co-repressor 2
Species: synthetic, synthetic
Database cross-references and differences (RAF-indexed):
- Heterogens: 471, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1kkqA (A:)
tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
haqlvqiikktesdaalhpllqeiyrdmy
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1kkqB (B:)
tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
haqlvqiikktesdaalhpllqeiyrdmy
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>1kkqC (C:)
tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
haqlvqiikktesdaalhpllqeiyrdmy
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>1kkqD (D:)
tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
haqlvqiikktesdaalhpllqeiyrdmy
- Chain 'E':
No sequence available.
- Chain 'F':
No sequence available.
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.