PDB entry 1kkq

View 1kkq on RCSB PDB site
Description: Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Class: transcription
Keywords: nuclear corepressor nuclear hormone receptors antagonist, TRANSCRIPTION
Deposited on 2001-12-10, released 2002-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: peroxisome proliferator activated receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Human
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kkqa_
  • Chain 'B':
    Compound: peroxisome proliferator activated receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Human
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kkqb_
  • Chain 'C':
    Compound: peroxisome proliferator activated receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Human
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kkqc_
  • Chain 'D':
    Compound: peroxisome proliferator activated receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: Human
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1kkqd_
  • Chain 'E':
    Compound: nuclear receptor co-repressor 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: nuclear receptor co-repressor 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: nuclear receptor co-repressor 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: nuclear receptor co-repressor 2
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 471, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1kkqA (A:)
    tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
    angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
    mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
    aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
    haqlvqiikktesdaalhpllqeiyrdmy
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1kkqB (B:)
    tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
    angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
    mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
    aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
    haqlvqiikktesdaalhpllqeiyrdmy
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1kkqC (C:)
    tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
    angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
    mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
    aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
    haqlvqiikktesdaalhpllqeiyrdmy
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1kkqD (D:)
    tadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklv
    angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
    mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
    aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
    haqlvqiikktesdaalhpllqeiyrdmy
    

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    No sequence available.