PDB entry 1ki6

View 1ki6 on RCSB PDB site
Description: crystal structure of thymidine kinase from herpes simplex virus type I complexed with a 5-iodouracil anhydrohexitol nucleoside
Class: phosphotransferase
Keywords: phosphotransferase, thymidine kinase, viridae, ds-DNA enveloped viruses, herpesviridae, alphaherpesvirinae, substrate analog, 5-iodouracil anhydrohexitol nucleoside
Deposited on 1998-05-18, released 1998-12-02
The last revision prior to the SCOP 1.73 freeze date was dated 2003-04-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.37 Å
R-factor: 0.223
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1
    Gene: TK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03176 (0-End)
      • conflict (234)
    Domains in SCOP 1.73: d1ki6a_
  • Chain 'B':
    Compound: Thymidine kinase
    Species: Human herpesvirus 1
    Gene: TK
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1ki6b_
  • Heterogens: SO4, AHU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ki6A (A:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagarphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1ki6A (A:)
mptllrvyidgphgmgkttttqlldivyvpepmtywrvlgasetianiyttqhrldqgei
sagdaavvmtsaqitmgmpyavtdavlaphiggeappaltlifdrhpiaallcypaaryl
mgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlamlaairrv
ygllantvrylqcggswredwgqlsarphigdtlftlfrapellapngdlynvfawaldv
lakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlartfaremge

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1ki6B (B:)
mptllrvyidgphgmgkttttqllvalgsrddivyvpepmtywrvlgasetianiyttqh
rldqgeisagdaavvmtsaqitmgmpyavtdavlaphiggeagsshapppaltlifdrhp
iaallcypaarylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpge
rldlamlaairrvygllantvrylqcggswredwgqlsgtavppqgaepqsnagprphig
dtlftlfrapellapngdlynvfawaldvlakrlrsmhvfildydqspagcrdallqlts
gmvqthvttpgsipticdlartfaremgean

    Sequence, based on observed residues (ATOM records): (download) 
    >1ki6B (B:)
mptllrvyidgphgmgkttttqllvaldivyvpepmtywrvlgasetianiyttqhrldq
geisagdaavvmtsaqitmgmpyavtdavlaphiggeappaltlifdrhpiaallcypaa
rylmgsmtpqavlafvalipptlpgtnivlgalpedrhidrlakrqrpgerldlamlaai
rrvygllantvrylqcggswredwgqlagprphigdtlftlfrapellapngdlynvfaw
aldvlakrlrsmhvfildydqspagcrdallqltsgmvqthvttpgsipticdlartfar
emge