PDB entry 1k7l

View 1k7l on RCSB PDB site
Description: The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide.
Class: transcription
Keywords: The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a coactivator peptide, TRANSCRIPTION
Deposited on 2001-10-19, released 2001-12-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.247
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: peroxisome proliferator activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1k7la_
  • Chain 'B':
    Compound: steroid receptor coactivator
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: peroxisome proliferator activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1k7lc_
  • Chain 'D':
    Compound: steroid receptor coactivator
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: peroxisome proliferator activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1k7le_
  • Chain 'F':
    Compound: steroid receptor coactivator
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: peroxisome proliferator activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1k7lg_
  • Chain 'H':
    Compound: steroid receptor coactivator
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
  • Heterogens: YT3, 544, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1k7lA (A:)
mkkghhhhhhgehdiedsetadlkslakriyeaylknfnmnkvkarvilsgkasnnppfv
ihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgfanl
dlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfd
famkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddi
flfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >1k7lA (A:)
dlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklvan
giqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1k7lC (C:)
mkkghhhhhhgehdiedsetadlkslakriyeaylknfnmnkvkarvilsgkasnnppfv
ihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgfanl
dlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfd
famkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddi
flfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >1k7lC (C:)
dlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklvan
giqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1k7lE (E:)
mkkghhhhhhgehdiedsetadlkslakriyeaylknfnmnkvkarvilsgkasnnppfv
ihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgfanl
dlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfd
famkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddi
flfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >1k7lE (E:)
dlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklvan
giqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1k7lG (G:)
mkkghhhhhhgehdiedsetadlkslakriyeaylknfnmnkvkarvilsgkasnnppfv
ihdmetlcmaektlvaklvangiqnkeaevrifhccqctsvetvteltefakaipgfanl
dlndqvtllkygvyeaifamlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfd
famkfnalelddsdislfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddi
flfpkllqkmadlrqlvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >1k7lG (G:)
dlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlvaklvan
giqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifaml
ssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfvaa
iiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvteha
qlvqiikktesdaalhpllqeiyrdmy

  • Chain 'H':
    No sequence available.