PDB entry 1k5d

View 1k5d on RCSB PDB site
Description: Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex
Class: signaling protein/signaling activator
Keywords: ran, ranbp1, rangap, gap, signal transduction, nuclear transport, GTP hydrolysis, ground state, complex (GTP-binding/gtpase activation), signaling protein/signaling activator complex
Deposited on 2001-10-10, released 2002-02-13
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.237
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5da_
  • Chain 'B':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5db_
  • Chain 'C':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.05: d1k5dc_
  • Chain 'D':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5dd_
  • Chain 'E':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5de_
  • Chain 'F':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.05: d1k5df_
  • Chain 'G':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5dg_
  • Chain 'H':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5dh_
  • Chain 'I':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.05: d1k5di_
  • Chain 'J':
    Compound: GTP-binding nuclear protein ran
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5dj_
  • Chain 'K':
    Compound: Ran-specific GTPase-activating protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d1k5dk_
  • Chain 'L':
    Compound: Ran GTPase activating protein 1
    Species: Schizosaccharomyces pombe [TaxId:4896]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P41391
      • see remark 999 (1)
    Domains in SCOPe 2.05: d1k5dl_
  • Heterogens: MG, GNP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1k5dA (A:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dA (A:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpded
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1k5dB (B:)
    maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
    endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
    vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
    aeklealsvkeetkedaeekq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dB (B:)
    nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
    ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
    flnaenaqkfktkfeecrkeieerek
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1k5dC (C:)
    marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
    dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
    htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
    ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
    kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
    kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
    qspepetseeekedkeladelskahi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dC (C:)
    arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
    leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
    tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
    tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
    swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
    mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >1k5dD (D:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dD (D:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpded
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >1k5dE (E:)
    maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
    endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
    vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
    aeklealsvkeetkedaeekq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dE (E:)
    nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
    ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
    flnaenaqkfktkfeecrkeieerek
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >1k5dF (F:)
    marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
    dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
    htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
    ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
    kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
    kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
    qspepetseeekedkeladelskahi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dF (F:)
    arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
    leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
    tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
    tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
    swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
    mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >1k5dG (G:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dG (G:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpded
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >1k5dH (H:)
    maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
    endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
    vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
    aeklealsvkeetkedaeekq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dH (H:)
    nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
    ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
    flnaenaqkfktkfeecrkeieerek
    

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >1k5dI (I:)
    marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
    dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
    htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
    ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
    kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
    kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
    qspepetseeekedkeladelskahi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dI (I:)
    arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
    leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
    tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
    tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
    swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
    mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee
    

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >1k5dJ (J:)
    maaqgepqvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpik
    fnvwdtagqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlc
    gnkvdikdrkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvamp
    alappevvmdpalaaqyehdlevaqttalpdedddl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dJ (J:)
    qvqfklvlvgdggtgkttfvkrhltgefekkyvatlgvevhplvfhtnrgpikfnvwdta
    gqekfgglrdgyyiqaqcaiimfdvtsrvtyknvpnwhrdlvrvcenipivlcgnkvdik
    drkvkaksivfhrkknlqyydisaksnynfekpflwlarkligdpnlefvampalappev
    vmdpalaaqyehdlevaqttalpded
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >1k5dK (K:)
    maaakdthedhdtstentdesnhdpqfepivslpeqeiktleedeeelfkmraklfrfas
    endlpewkergtgdvkllkhkekgairllmrrdktlkicanhyitpmmelkpnagsdraw
    vwnthadfadecpkpellairflnaenaqkfktkfeecrkeieerekkagsgkndhaekv
    aeklealsvkeetkedaeekq
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dK (K:)
    nhdpqfepivslpeqeiktleedeeelfkmraklfrfasendlpewkergtgdvkllkhk
    ekgairllmrrdktlkicanhyitpmmelkpnagsdrawvwnthadfadecpkpellair
    flnaenaqkfktkfeecrkeieerek
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >1k5dL (L:)
    marfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskk
    dleiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflsk
    htplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewa
    ktfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaial
    kswpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvide
    kmpdllflelngnrfseeddvvdeirevfstrgrgeldelddmeeltdeeeedeeeeaes
    qspepetseeekedkeladelskahi
    

    Sequence, based on observed residues (ATOM records): (download)
    >1k5dL (L:)
    arfsiegkslkldaittedeksvfavlleddsvkeivlsgntigteaarwlseniaskkd
    leiaefsdiftgrvkdeipealrlllqallkcpklhtvrlsdnafgptaqeplidflskh
    tplehlylhnnglgpqagakiaralqelavnkkaknapplrsiicgrnrlengsmkewak
    tfqshrllhtvkmvqngirpegiehllleglaycqelkvldlqdntfthlgssalaialk
    swpnlrelglndcllsargaaavvdafskleniglqtlrlqyneieldavrtlktvidek
    mpdllflelngnrfseeddvvdeirevfstrgrgeldelddmee