PDB entry 1jle

View 1jle on RCSB PDB site
Description: crystal structure of y188c mutant hiv-1 reverse transcriptase
Class: transferase
Keywords: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, drug resistance mutations, drug design, transferase
Deposited on 2001-07-16, released 2001-10-03
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.261
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hiv-1 rt, a-chain
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585 (0-End)
      • engineered and oxidized cys (187)
      • oxidized cys (279)
    Domains in SCOPe 2.01: d1jlea1, d1jlea2
  • Chain 'B':
    Compound: hiv-1 rt, b-chain
    Species: HIV-1 M:B_HXB2R [TaxId:11706]
    Gene: pol
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04585
      • engineered (187)
    Domains in SCOPe 2.01: d1jleb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1jleA (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlcvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnrgrqkvvtltdttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdqseselvnqiieqlikkekvylawvpahk
giggneqvdklvsagirkvl

    Sequence, based on observed residues (ATOM records): (download) 
    >1jleA (A:)
pispietvpvklkpgmdgpqwplteekikalveictemekegkiskinpyntpvfklvdf
relnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinn
etpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlcvgsdleigq
hrtkieelrqhllrwglttpkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqk
lvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyy
dpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittes
iviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaet
fyvdganrlgkagyvtnrgrqkvvtltdttnqktelqaiylalqdsglevnivtdsqyal
giiqaqpdqseselvnqiieqlikkekvylawvpahkgiggneqvd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1jleB (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlcvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetf

    Sequence, based on observed residues (ATOM records): (download) 
    >1jleB (B:)
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfqlgiphpaglkkkksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lcvgsdleigqhrtkieelrqhllrwelhpdkwtvqpivlpekdswtvndiqklvgklnw
asqiypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdli
aeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgkt
pkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepi