PDB entry 1jcq

View 1jcq on RCSB PDB site
Description: crystal structure of human protein farnesyltransferase complexed with farnesyl diphosphate and the peptidomimetic inhibitor l-739,750
Class: transferase
Keywords: ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, tumor regression, l-739,750, peptidomimetic, inhibitor
Deposited on 2001-06-11, released 2001-11-02
The last revision prior to the SCOP 1.73 freeze date was dated 2001-11-02, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.179
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein farnesyltransferase, alpha subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1jcqa_
  • Chain 'B':
    Compound: protein farnesyltransferase, beta subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1jcqb_
  • Heterogens: SUC, ZN, FPP, 739, ACY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1jcqA (A:)
maategvgeaaqggepgqpaqpppqphppppqqqhkeemaaeageavaspmddgfvslds
psyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrvlvewlr
dpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnnsvwnqr
yfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhstendsptnvqqeef

    Sequence, based on observed residues (ATOM records): (download) 
    >1jcqA (A:)
fvsldspsyvlyrdraewadidpvpqndgpnpvvqiiysdkfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllkslqkdlheemnyitaiieeqpknyqvwhhrrv
lvewlrdpsqelefiadilnqdaknyhawqhrqwviqefklwdnelqyvdqllkedvrnn
svwnqryfvisnttgyndravlerevqytlemiklvphnesawnylkgilqdrglskypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1jcqB (B:)
maspssftyycppssspvwseplyslrpeharerlqddsvetvtsieqakveekiqevfs
sykfnhlvprlvlqrekhfhylkrglrqltdayecldasrpwlcywilhslelldepipq
ivatdvcqflelcqspeggfgggpgqyphlaptyaavnalciigteeaydiinrekllqy
lyslkqpdgsflmhvggevdvrsaycaasvasltniitpdlfegtaewiarcqnweggig
gvpgmeahggytfcglaalvilkrerslnlksllqwvtsrqmrfeggfqgrcnklvdgcy
sfwqagllpllhralhaqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgksrdf
yhtcyclsglsiaqhfgsgamlhdvvlgvpenalqpthpvynigpdkviqattyflqkpv
pgfeelkdetsaepatd

    Sequence, based on observed residues (ATOM records): (download) 
    >1jcqB (B:)
sspvwseplyslrpeharerlqddsvetvtsieqakveekiqevfssykfnhlvprlvlq
rekhfhylkrglrqltdayecldasrpwlcywilhslelldepipqivatdvcqflelcq
speggfgggpgqyphlaptyaavnalciigteeaydiinrekllqylyslkqpdgsflmh
vggevdvrsaycaasvasltniitpdlfegtaewiarcqnweggiggvpgmeahggytfc
glaalvilkrerslnlksllqwvtsrqmrfeggfqgrcnklvdgcysfwqagllpllhra
lhaqgdpalsmshwmfhqqalqeyilmccqcpagglldkpgksrdfyhtcyclsglsiaq
hfgsgamlhdvvlgvpenalqpthpvynigpdkviqattyflqkpvpgfe