PDB entry 1im3

View 1im3 on RCSB PDB site
Description: Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax
Class: Viral protein/Immune system
Keywords: Beta sheet, Beta sandwhich, Immunoglobulin (Ig) fold, immunoglobulin (IG)-like domain, protein complex, alpha helix, Viral protein/Immune system COMPLEX
Deposited on 2001-05-09, released 2001-06-06
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.206
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3a1, d1im3a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: Beta 2-microglobulin
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • cloning artifact (0)
    Domains in SCOPe 2.02: d1im3b_
  • Chain 'C':
    Compound: Human T-cell lymphotropic virus type 1 Tax peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB AAA85845 (0-8)
  • Chain 'D':
    Compound: cytomegalovirus protein US2
    Species: Human herpesvirus 5 [TaxId:10359]
    Gene: US2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3d_
  • Chain 'E':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3e1, d1im3e2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: Beta 2-microglobulin
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • cloning artifact (0)
    Domains in SCOPe 2.02: d1im3f_
  • Chain 'G':
    Compound: Human T-cell lymphotropic virus type 1 Tax peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB AAA85845 (0-8)
  • Chain 'H':
    Compound: cytomegalovirus protein US2
    Species: Human herpesvirus 5 [TaxId:10359]
    Gene: US2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3h_
  • Chain 'I':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3i1, d1im3i2
  • Chain 'J':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: Beta 2-microglobulin
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • cloning artifact (0)
    Domains in SCOPe 2.02: d1im3j_
  • Chain 'K':
    Compound: Human T-cell lymphotropic virus type 1 Tax peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB AAA85845 (0-8)
  • Chain 'L':
    Compound: cytomegalovirus protein US2
    Species: Human herpesvirus 5 [TaxId:10359]
    Gene: US2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3l_
  • Chain 'M':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-A2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3m1, d1im3m2
  • Chain 'N':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: Beta 2-microglobulin
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • cloning artifact (0)
    Domains in SCOPe 2.02: d1im3n_
  • Chain 'O':
    Compound: Human T-cell lymphotropic virus type 1 Tax peptide
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • GB AAA85845 (0-8)
  • Chain 'P':
    Compound: cytomegalovirus protein US2
    Species: Human herpesvirus 5 [TaxId:10359]
    Gene: US2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1im3p_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3A (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3D (D:)
    pwfqiednrcyidngklfargsivgnmsrfvfdpkadyggvgenlyvhaddvefvpgesl
    kwnvrnldvmpifetlalrlvlqgdviwlrcvpel
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3E (E:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3F (F:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'G':
    No sequence available.

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3H (H:)
    pwfqiednrcyidngklfargsivgnmsrfvfdpkadyggvgenlyvhaddvefvpgesl
    kwnvrnldvmpifetlalrlvlqgdviwlrcvpel
    

  • Chain 'I':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3I (I:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3J (J:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3L (L:)
    pwfqiednrcyidngklfargsivgnmsrfvfdpkadyggvgenlyvhaddvefvpgesl
    kwnvrnldvmpifetlalrlvlqgdviwlrcvpel
    

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3M (M:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwe
    

  • Chain 'N':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3N (N:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1im3P (P:)
    pwfqiednrcyidngklfargsivgnmsrfvfdpkadyggvgenlyvhaddvefvpgesl
    kwnvrnldvmpifetlalrlvlqgdviwlrcvpel