PDB entry 1h7x

View 1h7x on RCSB PDB site
Description: dihydropyrimidine dehydrogenase (dpd) from pig, ternary complex of a mutant enzyme (c671a), nadph and 5-fluorouracil
Class: electron transfer
Keywords: electron transfer, flavin, iron-sulfur clusters, pyrimidine catabolism, 5-fluorouracil degradation, oxidoreductase
Deposited on 2001-01-19, released 2001-02-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.01 Å
R-factor: 0.171
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydropyrimidine dehydrogenase
    Species: SUS SCROFA [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
      • engineered mutation (670)
    Domains in SCOPe 2.07: d1h7xa1, d1h7xa2, d1h7xa3, d1h7xa4, d1h7xa5
  • Chain 'B':
    Compound: dihydropyrimidine dehydrogenase
    Species: SUS SCROFA [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
      • engineered mutation (670)
    Domains in SCOPe 2.07: d1h7xb1, d1h7xb2, d1h7xb3, d1h7xb4, d1h7xb5
  • Chain 'C':
    Compound: dihydropyrimidine dehydrogenase
    Species: SUS SCROFA [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
      • engineered mutation (670)
    Domains in SCOPe 2.07: d1h7xc1, d1h7xc2, d1h7xc3, d1h7xc4, d1h7xc5
  • Chain 'D':
    Compound: dihydropyrimidine dehydrogenase
    Species: SUS SCROFA [TaxId:9823]
    Gene: DPYD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q28943
      • conflict (59)
      • engineered mutation (670)
    Domains in SCOPe 2.07: d1h7xd1, d1h7xd2, d1h7xd3, d1h7xd4, d1h7xd5
  • Heterogens: SF4, FMN, FAD, NDP, URF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1h7xA (A:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

    Sequence, based on observed residues (ATOM records): (download) 
    >1h7xA (A:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrgl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1h7xB (B:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

    Sequence, based on observed residues (ATOM records): (download) 
    >1h7xB (B:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1h7xC (C:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

    Sequence, based on observed residues (ATOM records): (download) 
    >1h7xC (C:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1h7xD (D:)
mapvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfd
dikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdn
plgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqe
kmpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydv
vnfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqd
qgfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvf
lvfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwn
ededqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfagg
divgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemagl
kfinpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmy
gpgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeas
gadalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsi
araakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtt
iaralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallyl
ksieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeq
naafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcy
mtcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla
vnpvc

    Sequence, based on observed residues (ATOM records): (download) 
    >1h7xD (D:)
apvlskdvadiesilalnprtqshaalhstlakkldkkhwkrnpdkncfhceklennfdd
ikhttlgergalreamrclkcadapcqkscpthldiksfitsisnknyygaakmifsdnp
lgltcgmvcptsdlcvggcnlyateegsinigglqqfasevfkamnipqirnpclpsqek
mpeaysakiallgagpasiscasflarlgysditifekqeyvgglstseipqfrlpydvv
nfeielmkdlgvkiicgkslseneitlntlkeegykaafigiglpepktddifqgltqdq
gfytskdflplvaksskagmcachsplpsirgavivlgagdtafdcatsalrcgarrvfl
vfrkgfvniravpeevelakeekceflpflsprkvivkggrivavqfvrteqdetgkwne
dedqivhlkadvvisafgsvlrdpkvkealspikfnrwdlpevdpetmqtsepwvfaggd
ivgmanttvesvndgkqaswyihkyiqaqygasvsakpelplfytpvdlvdisvemaglk
finpfglasaapttsssmirrafeagwgfaltktfsldkdivtnvsprivrgttsgpmyg
pgqssflnielisektaaywcqsvtelkadfpdniviasimcsynkndwmelsrkaeasg
adalelnlsaphgmgergmglacgqdpelvrnicrwvrqavqipffakltpnvtdivsia
raakeggadgvtatntvsglmglkadgtpwpavgagkrttyggvsgtairpialravtti
aralpgfpilatggidsaesglqflhsgasvlqvcsavqnqdftviqdyctglkallylk
sieelqgwdgqspgteshqkgkpvpriaelmgkklpnfgpyleqrkkiiaeekmrlkeqn
aafpplerkpfipkkpipaikdvigkalqylgtfgelsnieqvvavideemcincgkcym
tcndsgyqaiqfdpethlptvtdtctgctlclsvcpiidcirmvsrttpyepkrglpla