PDB entry 1h2t

View 1h2t on RCSB PDB site
Description: Structure of the human nuclear cap-binding-complex (CBC) in complex with a cap analogue m7GpppG
Class: nuclear protein
Keywords: m7gcap, cap-binding-complex, rnp domain, mif4g domain, RNA maturation, RNA export, nuclear protein, RNA-binding
Deposited on 2002-08-16, released 2002-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-04-03, with a file datestamp of 2019-03-29.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'C':
    Compound: 80 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q09161 (634-722)
      • engineered mutation (459)
    • PDB 1H2T (633-633)
    Domains in SCOPe 2.08: d1h2tc1, d1h2tc2, d1h2tc3
  • Chain 'Z':
    Compound: 20 kda nuclear cap binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1h2tz_
  • Heterogens: GDP, 7MG, HOH

PDB Chain Sequences:

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1h2tC (C:)
ktsdanetedhleslickvgeksacslesnleglagvleadlpnykskilrllctvarll
pekltiyttlvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchv
iaapsmvamfenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifant
esylkrrqkthvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsi
lcealqhnlppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlh
ciikshwkerktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttlliel
cklqpgslpqvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsq
dpespkpkfvrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghs
valclavafkskatndeifsilkdvpnpnqdddddegfsfnplkievfvqtllhlaaksf
shsfsalakfhevfktlaesdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaav
anwifsselsrdftrlfvweilhstirkmnkhvgaqseqknlflvifqrfimiltehlvr
cetdgtsvltpwykncierlqqiflqhhqiiqqymvtlenllftaeldphilavfqqfca
lqa

    Sequence, based on observed residues (ATOM records): (download) 
    >1h2tC (C:)
dhleslickvgeksacslesnleglagvleadlpnykskilrllctvarllpekltiytt
lvgllnarnynfggefveamirqlkeslkannyneavylvrflsdlvnchviaapsmvam
fenfvsvtqeedvpqvrrdwyvyaflsslpwvgkelyekkdaemdrifantesylkrrqk
thvpmlqvwtadkphpqeeyldclwaqiqklkkdrwqerhilrpylafdsilcealqhnl
ppftppphtedsvypmprvifrmfdytddpegpvmpgshsverfvieenlhciikshwke
rktcaaqlvsypgknkiplnyhivevifaelfqlpapphidvmyttllielcklqpgslp
qvlaqatemlymrldtmnttcvdrfinwfshhlsnfqfrwswedwsdclsqdpespkpkf
vrevlekcmrlsyhqrildivpptfsalcpsnptciykygdessnslpghsvalclavaf
kskatndeifsilkdvpnpsfnplkievfvqtllhlaaksfshsfsalakfhevfktlae
sdegklhvlrvmfevwrnhpqmiavlvdkmirtqivdcaavanwifsselsrdftrlfvw
eilhstirkmnkhvgaqseqknlflvifqrfimiltehlvrcetdgtsvltpwykncier
lqqiflqhhqiiqqymvtlenllftaeldphilavfqqfcalqa

  • Chain 'Z':
    Sequence, based on SEQRES records: (download) 
    >1h2tZ (Z:)
msggllkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelf
sksgdikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfk
egrqygrgrsggqvrdeyrqdydagrggygklaqnq

    Sequence, based on observed residues (ATOM records): (download) 
    >1h2tZ (Z:)
llkalrsdsyvelsqyrdqhfrgdneeqekllkksctlyvgnlsfytteeqiyelfsksg
dikkiimgldkmkktacgfcfveyysradaenamryingtrlddriirtdwdagfkegrq
ygrgrsggqvrdeyrqdydagrggyg