PDB entry 1h08

View 1h08 on RCSB PDB site
Description: cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor
Class: transferase
Keywords: serine/threonine-protein kinase, mitosis, transferase
Deposited on 2002-06-11, released 2003-07-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-10-12, with a file datestamp of 2011-10-07.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.213
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1H08
    • Uniprot P24941 (0-297)
    Domains in SCOPe 2.07: d1h08a_
  • Heterogens: BYP, BWP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1h08A (A:)
    menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
    pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
    hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
    stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
    pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1h08A (A:)
    menfqkvekigegtygvvykarnkltgevvalkkivpstaireisllkelnhpnivklld
    vihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdl
    kpqnllintegaikladfglarafghevvtlwyrapeillgckyystavdiwslgcifae
    mvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppl
    dedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl