PDB entry 1gwr

View 1gwr on RCSB PDB site
Description: human oestrogen receptor alpha ligand-binding domain in complex with 17beta-oestradiol and tif2 nrbox3 peptide
Class: nuclear receptor
Keywords: nuclear receptor, transcription factor, transactivation, agonist, af2 coactivator , receptor, activator, transcripti regulation, DNA-binding, nuclear protein, zinc finger, ster binding, phosphorylation, polymorphism, alternative splicin
Deposited on 2002-03-22, released 2002-08-29
The last revision prior to the SCOP 1.75 freeze date was dated 2002-08-29, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.225
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: oestrogen receptor
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1gwra_
  • Chain 'B':
    Compound: oestrogen receptor
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1gwrb_
  • Chain 'C':
    Compound: transcription intermediary factor-2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: transcription intermediary factor-2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EST, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1gwrA (A:)
    slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
    pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
    fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
    tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydllleml
    dahrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1gwrA (A:)
    lalsltadqmvsalldaeppilyseyrpfseasmmglltnladrelvhminwakrvpgfv
    dltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdml
    latssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihlma
    kagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldahrl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >1gwrB (B:)
    slalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhminwakrv
    pgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmvei
    fdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvldkitd
    tlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydllleml
    dahrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1gwrB (B:)
    slalsltadqmvsalldaeppilyseydppfseasmmglltnladrelvhminwakrvpg
    fvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifd
    mllatssrfrmmnlqgeefvclksiillnsgvytftlksleekdhihrvldkitdtlihl
    makagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvplydlllemldahr
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.