PDB entry 1g8m

View 1g8m on RCSB PDB site
Description: crystal structure of avian atic, a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis at 1.75 ang. resolution
Class: transferase, hydrolase
Keywords: Homodimer, 2 functional domains; IMPCH domain = alpha/beta/alpha; AICAR Tfase = 2 alpha/beta/alpha domains, 1 alpha + beta domain, transferase, hydrolase
Deposited on 2000-11-17, released 2001-04-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.2
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aicar transformylase-imp cyclohydrolase
    Species: Gallus gallus [TaxId:9031]
    Gene: PURH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31335 (Start-592)
      • cloning artifact (60)
      • cloning artifact (88)
      • cloning artifact (158)
      • cloning artifact (210)
      • cloning artifact (288)
      • cloning artifact (312)
      • cloning artifact (367)
      • cloning artifact (387)
      • cloning artifact (476)
      • cloning artifact (511)
    Domains in SCOPe 2.06: d1g8ma1, d1g8ma2
  • Chain 'B':
    Compound: aicar transformylase-imp cyclohydrolase
    Species: Gallus gallus [TaxId:9031]
    Gene: PURH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31335 (Start-592)
      • cloning artifact (60)
      • cloning artifact (88)
      • cloning artifact (158)
      • cloning artifact (210)
      • cloning artifact (288)
      • cloning artifact (312)
      • cloning artifact (367)
      • cloning artifact (387)
      • cloning artifact (476)
      • cloning artifact (511)
    Domains in SCOPe 2.06: d1g8mb1, d1g8mb2
  • Heterogens: K, G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1g8mA (A:)
maarqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpe
mlggrvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpe
avekidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaf
thtaqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfin
lcdalnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltpl
asayarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkkn
ggycvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdli
vasiavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfk
agvkraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssd
affpfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1g8mA (A:)
rqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpemlg
grvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpeave
kidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaftht
aqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfinlcd
alnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltplasa
yarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkknggy
cvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdlivas
iavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfkagv
kraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssdaff
pfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1g8mB (B:)
maarqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpe
mlggrvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpe
avekidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaf
thtaqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfin
lcdalnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltpl
asayarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkkn
ggycvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdli
vasiavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfk
agvkraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssd
affpfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1g8mB (B:)
rqqlallsvsekaglvefarslnalglgliasggtatalrdaglpvrdvsdltgfpemlg
grvktlhpavhagilarnipednadmnkqdfslvrvvvcnlypfvktvsspgvtvpeave
kidiggvallraaaknharvtvvcdpadyssvakemaaskdkdtsvetrrhlalkaftht
aqydaaisdyfrkeyskgvsqlplrygmnphqspaqlyttrpklpltvvngspgfinlcd
alnawqlvkelkqalgipaaasfkhvspagaavgiplseeeaqvcmvhdlhktltplasa
yarsrgadrmssfgdfialsdicdvptakiisrevsdgvvapgyeeealkilskkknggy
cvlqmdpnyepddneirtlyglqlmqkrnnavidrslfknivtknktlpesavrdlivas
iavkytqsnsvcyakdgqvigigagqqsrihctrlagdkanswwlrhhprvlsmkfkagv
kraevsnaidqyvtgtigededlvkwqamfeevpaqlteaekkqwiakltavslssdaff
pfrdnvdrakrigvqfivapsgsaadevvieacnelgitlihtnlrlfhh