PDB entry 1f8u

View 1f8u on RCSB PDB site
Description: crystal structure of mutant e202q of human acetylcholinesterase complexed with green mamba venom peptide fasciculin-II
Class: hydrolase/toxin
Keywords: serine esterase, human acetylcholinesterase, hydrolase, snake toxin, hydrolase/hydrolase inhibitor, hydrolase-toxin complex
Deposited on 2000-07-05, released 2001-01-17
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.191
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22303
      • engineered (201)
    Domains in SCOPe 2.02: d1f8ua_
  • Chain 'B':
    Compound: fasciculin II
    Species: Dendroaspis angusticeps [TaxId:8618]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d1f8ub_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1f8uA (A:)
    egredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvv
    dattfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiyg
    ggfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlal
    qwvqenvaafggdptsvtlfgqsagaasvgmhllsppsrglfhravlqsgapngpwatvg
    mgearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfv
    pvvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefl
    agvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaa
    qgarvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmryw
    anfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkll
    satdtldeaerqwkaefhrwssymvhwknqfdhyskqdrcsdl
    

    Sequence, based on observed residues (ATOM records): (download)
    >1f8uA (A:)
    daellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdatt
    fqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggfy
    sgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwvq
    envaafggdptsvtlfgqsagaasvgmhllsppsrglfhravlqsgapngpwatvgmgea
    rrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdflsd
    tpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpqv
    sdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayvf
    ehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdpn
    eppkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsat
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1f8uB (B:)
    tmcyshtttsrailtncgenscyrksrrhppkmvlgrgcgcppgddnlevkcctspdkcn
    y