PDB entry 1e8w

View 1e8w on RCSB PDB site
Description: structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Class: phosphoinositide 3-kinase gamma
Keywords: phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, quercetin
Deposited on 2000-10-03, released 2000-11-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.265
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol 3-kinase catalytic subunit
    Species: SUS SCROFA [TaxId:9823]
    Gene: P120S144C
    Database cross-references and differences (RAF-indexed):
    • Uniprot O02697 (1-End)
      • expression tag (1)
      • conflict (363)
    Domains in SCOPe 2.06: d1e8wa1, d1e8wa2, d1e8wa3, d1e8wa4, d1e8wa5
  • Heterogens: QUE

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1e8wA (A:)
aaseetlafqrqlnaligydvtdvsnvhddeleftrrrlvtprmaevagrdpklyamhpw
vtskplpeyllkkitnncvfivihrsttsqtikvsaddtpgtilqsfftkmakkkslmdi
pesqnerdfvlrvcgrdeylvgetpiknfqwvrqclkngeeihlvldtppdpaldevrke
ewplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprtadltv
fveaniqygqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapal
sgktsaempspeskgkaqllyyvnlllidhrfllrhgeyvlhmwqlsgkgedqgsfnadk
ltsatnpdkensmsisilldnychpialpkhrptpdpegdrvraempnqlrkqleaiiat
dplnpltaedkellwhfryeslkdpkaypklfssvkwgqqeivaktyqllakrevwdqsa
ldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfl
lkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvidm
lqkvtidikslsaekydvssqvisqlkqklenlqnlnlpqsfrvpydpglkagalviekc
kvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesld
lcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlshwlkekcpieekf
qaaverfvyscagycvatfvlgigdrhndnimisetgnlfhidfghilgnyksflginke
rvpfvltpdflfvmgtsgkktslhfqkfqdvcvkaylalrhhtnlliilfsmmlmtgmpq
ltskedieyirdaltvgkseedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhs
a

    Sequence, based on observed residues (ATOM records): (download) 
    >1e8wA (A:)
aseetlafqrqlnaligydvtdvsnvhddeleftrrrlvtprmaevagrdpklyamhpwv
tskplpeyllkkitnncvfivihrsttsqtikvsaddtpgtilqsfftkmdfvlrvcgrd
eylvgetpiknfqwvrqclkngeeihlvldtppdpaldevrkevslwdcdrkfrvkirgi
dipvlprtadltvfveaniqygqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgal
lnlqiycgqllyyvnlllidhrfllrhgeyvlhmwqlsfnadkltsatnpdkensmsisi
lldnychpialpkhempnqlrkqleaiiatdplnpltaedkellwhfryeslkdpkaypk
lfssvkwgqqeivaktyqllakrevwdqsaldvgltmqlldcnfsdenvraiavqklesl
edddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqq
rfavileaylrgcgtamlhdftqqvqvidmlqkvtidikslsaekydvssqvisqlkqkl
enlqnlnlpqsfrvpydpglkagalviekckvmaskkkplwlefkcadptalsnetigii
fkhgddlrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiaki
qqstvgntgafkdevlshwlkekcpieekfqaaverfvyscagycvatfvlgigdrhndn
imisetgnlfhidfgnkervpfvltpdflfvmgtsgkktslhfqkfqdvcvkaylalrhh
tnlliilfsmmlmtgmpqltskedieyirdaltvgkseedakkyfldqievcrdkgwtvq
fnwflhlvlgi