PDB entry 1c70

View 1c70 on RCSB PDB site
Description: alternate binding site for the p1-p3 group of a class of potent hiv-1 protease inhibitors as a result of concerted structural change in 80's loop.
Class: hydrolase
Keywords: hydrolase
Deposited on 1999-12-29, released 2000-12-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.16
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (protease)
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: NY5 ISOLATE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1c70a_
  • Chain 'B':
    Compound: protein (protease)
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: NY5 ISOLATE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d1c70b_
  • Heterogens: L75, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1c70A (A:)
    pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
    qilieicghkaigtvlvgptpvniigrnlltqigctlnf
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1c70B (B:)
    pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
    qilieicghkaigtvlvgptpvniigrnlltqigctlnf