PDB entry 1c5f

View 1c5f on RCSB PDB site
Description: crystal structure of the cyclophilin-like domain from brugia malayi complexed with cyclosporin a
Class: isomerase/immunosuppressant
Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin
Deposited on 1999-11-22, released 1999-12-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-27, with a file datestamp of 2011-07-22.
Experiment type: XRAY
Resolution: 2.47 Å
R-factor: 0.201
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fa_
  • Chain 'B':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'C':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fc_
  • Chain 'D':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'E':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fe_
  • Chain 'F':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'G':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fg_
  • Chain 'H':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'I':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fi_
  • Chain 'J':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'K':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fk_
  • Chain 'L':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'M':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fm_
  • Chain 'N':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Chain 'O':
    Compound: peptidyl-prolyl cis-trans isomerase 1
    Species: Brugia malayi [TaxId:6279]
    Gene: BMCYP-1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1c5fo_
  • Chain 'P':
    Compound: cyclosporin a
    Species: Tolypocladium inflatum, synthetic [TaxId:29910]
    Database cross-references and differences (RAF-indexed):
    • NOR NOR00033 (0-10)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1c5fA (A:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1c5fC (C:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1c5fE (E:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fE (E:)
kdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgst
fhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsqf
fitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1c5fG (G:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fG (G:)
rrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgstfh
rviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsqffi
tttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1c5fI (I:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fI (I:)
drrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgstf
hrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsqff
itttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1c5fK (K:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fK (K:)
kkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgs
tfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsq
ffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >1c5fM (M:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fM (M:)
kkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgs
tfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsq
ffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >1c5fO (O:)
mskkdrrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhyk
gstfhrviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntng
sqffitttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

    Sequence, based on observed residues (ATOM records): (download) 
    >1c5fO (O:)
rrrvfldvtidgnlagrivmelyndiaprtcnnflmlctgmagtgkisgkplhykgstfh
rviknfmiqggdftkgdgtggesiyggmfddeefvmkhdepfvvsmankgpntngsqffi
tttpaphlnnihvvfgkvvsgqevvtkieylktnsknrpladvvilncgelv

  • Chain 'P':
    No sequence available.