PDB entry 1c3e
View 1c3e on RCSB PDB site
Description: new insights into inhibitor design from the crystal structure and nmr studies of e. coli gar transformylate in complex with beta-gar and 10-formyl-5,8,10-trideazafolic acid.
Class: transferase
Keywords: purine biosynthesis, anti-cancer agent, inhibitor complex
Deposited on
1999-07-27, released
1999-12-29
The last revision prior to the SCOP 1.75 freeze date was dated
1999-12-29, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.227
AEROSPACI score: 0.48
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: glycinamide ribonucleotide transformylase
Species: Escherichia coli
Gene: PURN
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1c3ea_ - Chain 'B':
Compound: glycinamide ribonucleotide transformylase
Species: Escherichia coli
Gene: PURN
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.75: d1c3eb_ - Heterogens: NHR, GAR, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1c3eA (A:)
mnivvlisgngsnlqaiidacktnkikgtvravfsnkadafglerarqagiathtliasa
fdsreaydreliheidmyapdvvvlagfmrilspafvshyagrllnihpsllpkypglht
hrqalengdeehgtsvhfvtdeldggpvilqakvpvfagdsedditarvqtqehaiyplv
iswfadgrlkmhenaawldgqrlppqgya
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1c3eB (B:)
mnivvlisgngsnlqaiidacktnkikgtvravfsnkadafglerarqagiathtliasa
fdsreaydreliheidmyapdvvvlagfmrilspafvshyagrllnihpsllpkypglht
hrqalengdeehgtsvhfvtdeldggpvilqakvpvfagdsedditarvqtqehaiyplv
iswfadgrlkmhenaawldgqrlppqgya