SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily b.1.29: Macroglobulin

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2033537Superfamily b.1.29: Macroglobulin [254121] (8 families) (S)
    C3 MG domains possibly arose by gene duplication according to PubMed 16177781; PubMed 17608619; possibly related to immunoglobulins according to Pfam clan annotations


  1. 2033538b.1.29.1: Alpha-macroglobulin receptor domain [254148] (4 protein domains)
    Pfam PF07677
  2. 2033556b.1.29.2: Complement C3 MG1-like [254155] (2 protein domains)
  3. 2033564b.1.29.3: Complement C3 MG2-like [254156] (3 protein domains)
    Pfam PF01835
  4. 2033576b.1.29.4: Complement C3 MG3-like [254157] (2 protein domains)
  5. 2033584b.1.29.5: Complement C3 MG4-like [254158] (2 protein domains)
  6. 2033592b.1.29.6: Complement C3 MG5-like [254159] (2 protein domains)
    Pfam PF07703
  7. 2033600b.1.29.7: Complement C3 MG6-like [254160] (2 protein domains)
  8. 2033608b.1.29.8: Complement C3 MG7-like [254161] (2 protein domains)

More info for Superfamily b.1.29: Macroglobulin

Timeline for Superfamily b.1.29: Macroglobulin: