SCOPe 2.06: Domain d1uu3a_: 1uu3 A:

Lineage for d1uu3a_ (1uu3 A:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d1uu3a_: 1uu3 A: [99999]
   complexed with gol, ly4, so4

Details for d1uu3a_

PDB Entry: 1uu3, 1.7 Å

PDB Description: structure of human pdk1 kinase domain in complex with ly333531

PDB Compounds: (A:) 3-phosphoinositide dependent protein kinase-1

SCOPe Domain Sequences for d1uu3a_:

Sequence, based on SEQRES records:

>d1uu3a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspe
llteksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardl
vekllvldatkrlgceemegygplkahpffesvtwenlhqqtppklta

Sequence, based on observed residues (ATOM records):

>d1uu3a_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
qprkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerd
vmsrldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsa
leylhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksacks
sdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldat
krlgceemegygplkahpffesvtwenlhqqtppklta

Timeline for d1uu3a_:

• d1uu3a_ first appeared in SCOP 1.67
  
• d1uu3a_ appears in SCOPe 2.05
  
• d1uu3a_ appears in SCOPe 2.07
  
• d1uu3a_ appears in the current release, SCOPe 2.08