SCOPe 2.06: Domain d1umbc_: 1umb C:

Lineage for d1umbc_ (1umb C:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (9 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (5 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)

8. Domain d1umbc_: 1umb C: [99590]
   Other proteins in same PDB: d1umbb1, d1umbb2, d1umbd1, d1umbd2
   complexed with mg, tdp

Details for d1umbc_

PDB Entry: 1umb, 2.1 Å

PDB Description: branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form

PDB Compounds: (C:) 2-oxo acid dehydrogenase alpha subunit

SCOPe Domain Sequences for d1umbc_:

Sequence; same for both SEQRES and ATOM records:

>d1umbc_ c.36.1.11 (C:) Branched-chain alpha-keto acid dehydrogenase, PP module {Thermus thermophilus [TaxId: 274]}
hrfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgkts
fiapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkg
rqmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwya
ginfaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdvlasyy
vvkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprfrrfle
arglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqeallke
e

Timeline for d1umbc_:

• d1umbc_ first appeared in SCOP 1.67
  
• d1umbc_ appears in SCOPe 2.05
  
• d1umbc_ appears in SCOPe 2.07
  
• d1umbc_ appears in the current release, SCOPe 2.08