SCOP 1.75: Domain d1um9c_: 1um9 C:

Lineage for d1um9c_ (1um9 C:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families)
   there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
   two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules

5. Family c.36.1.11: Branched-chain alpha-keto acid dehydrogenase PP module [88766] (4 proteins)
   parent family to TK and PFOR
   heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module

6. Protein Branched-chain alpha-keto acid dehydrogenase, PP module [88767] (2 species)

7. Species Thermus thermophilus [TaxId:274] [102337] (4 PDB entries)

8. Domain d1um9c_: 1um9 C: [99584]
   Other proteins in same PDB: d1um9b1, d1um9b2, d1um9d1, d1um9d2
   complexed with so4

Details for d1um9c_

PDB Entry: 1um9, 2.2 Å

PDB Description: branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8 in apo-form

PDB Compounds: (C:) 2-oxo acid dehydrogenase alpha subunit

SCOP Domain Sequences for d1um9c_:

Sequence, based on SEQRES records:

>d1um9c_ c.36.1.11 (C:) Branched-chain alpha-keto acid dehydrogenase, PP module {Thermus thermophilus [TaxId: 274]}
rfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgktsf
iapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkgr
qmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwyag
infaavqgapavfiaennfyaisvdyrhqthsptiadkahafgipgylvdgmdvlasyyv
vkeaverarrgegpslvelrvyrygphssadddsryrpkeevafwrkkdpiprfrrflea
rglwneeweedvreeiraelerglkeaeeagpvppewmfedvfaekpwhllrqeallkee
l

Sequence, based on observed residues (ATOM records):

>d1um9c_ c.36.1.11 (C:) Branched-chain alpha-keto acid dehydrogenase, PP module {Thermus thermophilus [TaxId: 274]}
rfetfteepirligeegewlgdfpldlegeklrrlyrdmlaarmlderytilirtgktsf
iapaagheaaqvaiahairpgfdwvfpyyrdhglalalgiplkellgqmlatkadpnkgr
qmpehpgskalnfftvaspiashvppaagaaismkllrtgqvavctfgdgatsegdwyag
infaavqgapavfiaennfptiadkahafgipgylvdgmdvlasyyvvkeaverarrgeg
pslvelrvyrygphssaddrkkdpiprfrrflearglwneeweedvreeiraelerglke
aeeagpvppewmfedvfaekpwhllrqeallkeel

Timeline for d1um9c_:

• d1um9c_ first appeared in SCOP 1.67
  
• d1um9c_ appears in SCOP 1.73
  
• d1um9c_ appears in SCOPe 2.01
  
• d1um9c_ appears in the current release, SCOPe 2.08