SCOPe 2.08: Domain d1uk0b1: 1uk0 B:1-137

Lineage for d1uk0b1 (1uk0 B:1-137)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.41: Domain of poly(ADP-ribose) polymerase [47586] (1 superfamily)
   core: 4 helices: bundle; unusual topology

4. Superfamily a.41.1: Domain of poly(ADP-ribose) polymerase [47587] (2 families)
   duplication: consists of 2 helix-loop-helix structural repeats
   automatically mapped to Pfam PF02877

5. Family a.41.1.1: Domain of poly(ADP-ribose) polymerase [47588] (1 protein)

6. Protein Domain of poly(ADP-ribose) polymerase [47589] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101198] (8 PDB entries)
   Uniprot P09874 661-1010

8. Domain d1uk0b1: 1uk0 B:1-137 [99479]
   Other proteins in same PDB: d1uk0a2, d1uk0b2
   complexed with frm

Details for d1uk0b1

PDB Entry: 1uk0, 3 Å

PDB Description: Crystal structure of catalytic domain of human poly(ADP-ribose) polymerase with a novel inhibitor

PDB Compounds: (B:) Poly [ADP-ribose] polymerase-1

SCOPe Domain Sequences for d1uk0b1:

Sequence; same for both SEQRES and ATOM records:

>d1uk0b1 a.41.1.1 (B:1-137) Domain of poly(ADP-ribose) polymerase {Human (Homo sapiens) [TaxId: 9606]}
ksklpkpvqdlikmifdvesmkkamveyeidlqkmplgklskrqiqaaysilsevqqavs
qgssdsqildlsnrfytliphdfgmkkppllnnadsvqakvemldnlldievaysllrgg
sddsskdpidvnyeklk

Timeline for d1uk0b1:

• d1uk0b1 first appeared in SCOP 1.67
  
• d1uk0b1 appears in SCOPe 2.07