SCOP 1.75: Domain d1udub_: 1udu B:

Lineage for d1udub_ (1udu B:)

1. Root: SCOP 1.75

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (5 families)

5. Family a.211.1.2: PDEase [48548] (6 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (15 PDB entries)
   Uniprot O76074 534-860

8. Domain d1udub_: 1udu B: [99223]
   complexed with cia, mg, zn

Details for d1udub_

PDB Entry: 1udu, 2.83 Å

PDB Description: Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)

PDB Compounds: (B:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOP Domain Sequences for d1udub_:

Sequence, based on SEQRES records:

>d1udub_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkii
kqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqq
riaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvs
edcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d1udub_ a.211.1.2 (B:) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
trelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhevlc
rwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshdld
hrgvnnsyychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlal
yikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateff
dqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealthvsedcfplldgcr
knrqkwqalaeqq

Timeline for d1udub_:

• d1udub_ first appeared in SCOP 1.67
  
• d1udub_ appears in SCOP 1.73
  
• d1udub_ appears in SCOPe 2.01
  
• d1udub_ appears in the current release, SCOPe 2.08