SCOPe 2.06: Domain d1ua6l_: 1ua6 L:

Lineage for d1ua6l_ (1ua6 L:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (16 species)
   VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (220 PDB entries)
   Uniprot P01645 1-106 # 95% sequense identity; KV5L_MOUSE Ig kappa chain V-V region HP 93G7 ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! SQ NA # humanized antibody ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01642 21-115 # ! KV5I_MOUSE Ig kappa chain V-V region L7 precursor

8. Domain d1ua6l_: 1ua6 L: [99130]
   Other proteins in same PDB: d1ua6h1, d1ua6h2, d1ua6y_
   part of Fv HyHEL-10
   mutant

Details for d1ua6l_

PDB Entry: 1ua6, 1.9 Å

PDB Description: crystal structure of hyhel-10 fv mutant sfsf complexed with hen egg white lysozyme complex

PDB Compounds: (L:) lysozyme binding Ig kappa chain V23-J2 region

SCOPe Domain Sequences for d1ua6l_:

Sequence; same for both SEQRES and ATOM records:

>d1ua6l_ b.1.1.1 (L:) Immunoglobulin light chain kappa variable domain, VL-kappa {Mouse (Mus musculus), cluster 4 [TaxId: 10090]}
divltqspatlsvtpgnsvslscrasqsignnlhwyqqkshesprllikyasqsisgips
rfsgsgsgtdftlsinsvetedfgmyfcqqsnswpytfgggtkleik

Timeline for d1ua6l_:

• d1ua6l_ first appeared in SCOP 1.67
  
• d1ua6l_ appears in SCOPe 2.05
  
• d1ua6l_ appears in SCOPe 2.07
  
• d1ua6l_ appears in the current release, SCOPe 2.08