SCOPe 2.03: Domain d1t2ea2: 1t2e A:164-331

Lineage for d1t2ea2 (1t2e A:164-331)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (18 species)

7. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (17 PDB entries)

8. Domain d1t2ea2: 1t2e A:164-331 [99087]
   Other proteins in same PDB: d1t2ea1
   complexed with gol, nai, oxm; mutant

Details for d1t2ea2

PDB Entry: 1t2e, 1.85 Å

PDB Description: plasmodium falciparum lactate dehydrogenase s245a, a327p mutant complexed with nadh and oxamate

PDB Compounds: (A:) l-lactate dehydrogenase

SCOPe Domain Sequences for d1t2ea2:

Sequence; same for both SEQRES and ATOM records:

>d1t2ea2 d.162.1.1 (A:164-331) Lactate dehydrogenase {Malaria parasite (Plasmodium falciparum) [TaxId: 5833]}
ggvldtsrlkyyisqklnvcprdvnahivgahgnkmvllkryitvggiplqefinnklis
daeleaifdrtvntaleivnlhaapyvapaaaiiemaesylkdlkkvlicstllegqygh
sdifggtpvvlgangveqvielqlnseekakfdeaiaetkrmkplahh

Timeline for d1t2ea2:

• d1t2ea2 first appeared in SCOP 1.67
  
• d1t2ea2 appears in SCOPe 2.02
  
• d1t2ea2 appears in SCOPe 2.04
  
• d1t2ea2 appears in the current release, SCOPe 2.08