SCOP 1.67: Domain d1t2ad_: 1t2a D:

Lineage for d1t2ad_ (1t2a D:)

1. Root: SCOP 1.67

2. Class c: Alpha and beta proteins (a/b) [51349] (130 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (11 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (40 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein GDP-mannose 4,6-dehydratase [51759] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [102135] (1 PDB entry)

8. Domain d1t2ad_: 1t2a D: [99081]
   complexed with gdp, ndp

Details for d1t2ad_

PDB Entry: 1t2a, 1.84 Å

PDB Description: Crystal structure of human GDP-D-mannose 4,6-dehydratase

SCOP Domain Sequences for d1t2ad_:

Sequence, based on SEQRES records:

>d1t2ad_ c.2.1.2 (D:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens)}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlyknpqahiegnmkl
hygdltdstclvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktc
glinsvkfyqastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfav
ngilfnhesprrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlm
lqndepedfviatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlk
yyrptevdflqgdctkakqklnwkprvafdelvremvhadvelmrt

Sequence, based on observed residues (ATOM records):

>d1t2ad_ c.2.1.2 (D:) GDP-mannose 4,6-dehydratase {Human (Homo sapiens)}
rnvalitgitgqdgsylaefllekgyevhgivrrsssfntgriehlynmklhygdltdst
clvkiinevkpteiynlgaqshvkisfdlaeytadvdgvgtlrlldavktcglinsvkfy
qastselygkvqeipqkettpfyprspygaaklyaywivvnfreaynlfavngilfnhes
prrganfvtrkisrsvakiylgqlecfslgnldakrdwghakdyveamwlmlqndepedf
viatgevhsvrefveksflhigktivwegknenevgrcketgkvhvtvdlkyyrptevdf
lqgdctkakqklnwkprvafdelvremvhadvelmrt

Timeline for d1t2ad_:

• d1t2ad_ is new in SCOP 1.67
  
• d1t2ad_ appears in SCOP 1.69
  
• d1t2ad_ appears in the current release, SCOPe 2.08